RAA干扰及其应用的研究进展  

Progress in RNAi and its application

作　　者：唐孝青[1] 李红生[1] 

机构地区：[1]西北农林科技大学,陕西杨凌712100

出　　处：《现代生物医学进展》2007年第5期787-789,共3页Progress in Modern Biomedicine

基　　金：西北农林科技大学国家生命科学与技术人才培养基地学生科技创新基金(200607)

摘　　要：RNA干扰作用(RNA interference,RNAi)是由双链RNA(double-stranded RNA,dsRNA)引发的转录后基因沉默机制(post transcriptional gene silencing,PTGs)。RNAi主要是指dsRNA分子进入细胞内,特异性降解与之同源的mRNA,从而特异高效的抑制相应基因表达活性的现象。它不但是研究基因功能的有力工具,而且为特异性基因治疗提供了新的技术手段。本文介绍RNAi的作用机制与应用的研究进展。RNA interference （RNAi） is a post-transcriptional gene silencing induced by introduction of double-stranded RNA （dsRNA）. It＇s a process of sequence-specific gene silence,which can specifically and effectively suppress the activity of corresponding mRNAs induced by double-stranded dsRNA. This is a highly specifically mechanism that involved in kinds of proteins. It＇s not only be a powerful tool in gene functional research, but also provides a new technique for gene therapy. RNAi not only is a powerful method for studying genes,but also offers new techniques for the therapy of specific gene.This paper introduces the research progress in the mechanisms and appfication of RNAi.

关 键 词：RNA干扰作用 小分子干扰RNA 双链RNA 基因沉默 

分 类 号：Q75[生物学—分子生物学] Q78