HPLC法测定心舒宝片中丹酚酸B的含量  

Determination of salvianolic acid B in Xinshubao tablets

作　　者：邹义栩[1] 

机构地区：[1]福建省药品检验所,福州350001

出　　处：《海峡药学》2007年第5期32-33,共2页Strait Pharmaceutical Journal

摘　　要：目的建立高效液相色谱法测定心舒宝片中丹酚酸B含量的方法。方法采用Hypersil-ODS_2色谱柱,以甲醇-1%甲酸溶液(37: 63)为流动相,检测波长为286nm。结果丹酚酸B在0．17472～8．736μg范围内与峰面积呈良好的线性关系,相关系数为0．99199,平均回收率为99．41%,RSD=2．04%。结论本法快速简便,精密度好,灵敏度高,可作为控制心舒宝片质量的方法。OBJECTIVE To determinate salvianolic acid B in Xinshubao tablets by HPLC. METHODS Hypersil - ODS2 column was used with methanol： 1% formic acid （ 37： 63） as mobile phase. Detection wavelength was set at 286nm. RESULTS Good linearity of salvianolic acid B was obtatined （r = 0. 9999 ）within the range of 0. 17472- 8. 736μg. The average recovery was 99.41% , repeatability was good, and RSD was 2. 04%. CONCLUSION The method is simple ,rapid, reproducible and accurate, and can be for the drug control

关 键 词：心舒宝 丹酚酸B HPLC 

分 类 号：R927.2[医药卫生—药学]