新型抗肿瘤药物2-[2-7-氯喹喔啉-2-氧吡啶-4-氧]丙酸的设计合成及表征  

Design and synthesis of a novel antitumor reagent XK469 derivatives

作　　者：苏爱华[1] 林建荣[2] 

机构地区：[1]福建卫生职业技术学院,福州350101 [2]福建师范大学,福州350007

出　　处：《海峡药学》2007年第5期79-80,共2页Strait Pharmaceutical Journal

摘　　要：目的对XK469进行结构改造，设计和合成一种新型喹喔啉类抗肿瘤药物。方法以2，4-二羟基吡啶和2，7-二氨喹喔啉为原料，在喹喔啉的2位引入一个吡啶环结构单元，合成了一种新型喹喔啉衍生物。结果目标产物利用IR，MS，^1HNMR和元素分析进行结构确认。结论本文合成了一种新型抗肿瘤化合物，有望成为XK469的替代品。OBJECTIVE To design and synthesize a novel quinoxaline derivative as antitumor reagent. METHODS Using 2,7-dichloroquinoxaline and 2,4-pyridinediol as material,introducing a pyridine to the new quinoxaline derivatives. RESULTS The structures of the target molecules were characterized by elemental analysis, ^1HNMR, MS, and IR. CONCLUSION A novel potential antitumor reagent was synthesized and it can be a good representation of the knowing antitumor reagent XK469.

关 键 词：XK469 合成 抗肿瘤药物 

分 类 号：R927.1[医药卫生—药学] R914.5