氯唑沙宗的电化学行为及测定  

Electrochemical Behavior of Chlorzoxazone and Its Practical Application

作　　者：马淮凌[1] 曹广秀[1] 李纪钦[1] 

机构地区：[1]商丘师范学院化学系,河南商丘476000

出　　处：《分析测试学报》2007年第3期352-355,共4页Journal of Instrumental Analysis

基　　金：河南省自然科学基金(0511020300);河南省科技攻关项目资助(20055001)

摘　　要：建立灵敏快速测定氯唑沙宗的新方法。在0．24mol·L^-1 KH2P04-Na2HPO4（pH6．81±0．1）支持电解质中，氯唑沙宗于0．80V（vs.SCE）电位处产生一还原波。加入过二硫酸钾后，该还原波峰电流增加约10倍，峰电位基本不变，产生一极谱催化波。其二阶导数峰电流Ip＂与氯唑沙宗的浓度在2．0×10^-7～8．0×10^-5mo1·L^-1范围内呈良好线性关系（r=0．9981，n=8），检出限为1．0×10^-7mol·L^-1。该方法可用于药剂中氯唑沙宗含量的测定。A novel method for the determination of chlorzoxazone is established. The reduction wave of chlorzoxazone appears at 0.80 V （vs. SCE） in 0. 24 mol · L^- 1 KH2PO4 - Na2 HPO4 （ pH 6. 81 ± 0. 1 ） supporting electrolyte. In the presence of 0. 01 mol · L^-1 K2S2O8, the reduction wave is catalyzed to produce a parallel catalytic wave. The peak current of the catalytic wave is 10 times higher than that of the corresponding reduction wave. Based on the catalytic wave, a novel method for the determination of chlorzoxazone is proposed. The peak current of the catalytic wave is rectilinear to chlorzoxazone concentration in the range of 2. 0 × 10^-7 -8.0 × 10 ^-5 mol · L^-1. The detection limit is 1.0 ×10^-7 mol · L^-1 The proposed method can be applied to the direct determination of chlorzoxazone in pharmaceuticals and urine without preliminary separation.

关 键 词：氯唑沙宗 过硫酸盐 极谱催化波 线性单扫描极谱法 

分 类 号：O657.1[理学—分析化学] R971.8[理学—化学]