蛇毒抗高凝状态酶对小鼠骨髓造血系统的影响  

Effects of antihypercoagulability state enzyme of snake venom on bone marrow hematopoietic system in mice

作　　者：朱伟杰[1] 张正明[1] 许力[1] 芮景[1] 

机构地区：[1]皖南医学院附属弋矶山医院普外科,安徽芜湖241001

出　　处：《皖南医学院学报》2007年第2期83-84,88,共3页Journal of Wannan Medical College

基　　金：安徽省教育厅自然科学基金项目(2004kj347)

摘　　要：目的:研究蛇毒抗高凝状态酶(AHCSE)对实验性小鼠骨髓造血系统的影响和作用机制。方法:将小鼠随机分为四组,分别用AHCSE,阿霉素,AHCSE+阿霉素,生理盐水经尾静脉注射,10d后观察并测定血清白细胞介素-3(IL-3)含量,骨髓粒细胞比例及粒红比,脾系数。结果:蛇毒抗高凝状态酶能刺激骨髓造血细胞显著增生,血清IL-3含量,骨髓粒细胞比例及粒红比,脾系数AHCSE较其他三组明显增加,有统计学意义(P<0.05)。结论:AHCSE能显著刺激骨髓增生可能与激活细胞免疫机制使细胞因子IL-3增加有关。To investigate the proliferative effects and mechanism of the antihypercoagulability state enzyme on bone marrow hematopoietic systems in experimental mice. Methods： 40 mice were randomly allocated to four groups by intravenous injection of AHCSE, ADM,AHCSE with ADM or normal saline respectively. The contents of interleukin-3（Multi-CSF）, percentage of bone marrow granular leuko-cytes and G/E and spleen body ratio were determined in ten days. Results ： AHCSE could stimulate myeloid elements to hyperplasy and increase the granular leukocytes percentage and G/E and spleen body ratio in comparison with the control groups, which had significant statistical difference（ P 〈 0.05 ）. Conclusion ： AHCSE can obviously stimulate bone marrow hemopoietic systems to hyperplasy, which may be correlated with the interleukin-3 multiplication by active cell immunologic mechanism.

关 键 词：蛇毒抗高凝状态酶 阿霉素 骨髓造血系统 IL-3 

分 类 号：R973.2[医药卫生—药品]