转化生长因子β_1与高血压靶器官损害的关系  

Correlation between TGF-β_1 and hypertensive target organ damage

作　　者：刘玉英[1] 王立启[2] 朱世明[2] 

机构地区：[1]山东大学医学院,山东济南250012 [2]济南市中心医院心内科,山东济南250013

出　　处：《山东大学学报（医学版）》2007年第5期495-498,共4页Journal of Shandong University:Health Sciences

摘　　要：目的：探讨血清转化生长因子β1 （TGFβ1）与原发性高血压（EH）靶器官损害之间的关系及其作用机制.方法：82例EH患者,按照尿白蛋白/肌酐比（albumin-to-creatinine ratio, ACR）分为3组：ACR≥300 mg/g为临床蛋白尿组（A组,28例）;30 mg/g＜ACR＜300 mg/g为微量蛋白尿组（B组,31例）;ACR≤30 mg/g为无蛋白尿组（C组,23例）.采用双抗体夹心ELISA法测定空腹血清转化生长因子β1（TGFβ1）,放射性免疫分析法测定血浆血管紧张素Ⅱ（AngⅡ）水平及尿ACR;应用超声心动图测定并计算左室重量指数（LVMI）.比较3组间上述指标的差异性,分析EH组TGFβ1与LVMI、ACR和AngⅡ的相关性.结果：血清TGFβ1水平A组明显高于B组和C组（P＜0.01）,B组和C组比较差异有统计学意义（P＜0.05）.相关分析表明,EH患者血清TGFβ1水平与血浆ACR、AngⅡ、LVMI呈正相关（P＜0.05～0.01）.结论：TGFβ1在原发性高血压心肾靶器官损害的发生发展过程中起重要作用.Objective： To investigate the relationship between the serum level of TGFβ1, and hypertensive target organ damage in patients with essential hypertension（EH）. Methods： Eighty-two patients with EH were enrolled and divided into three groups based on the albumin-to-creatinine ratio （ACR） ： a group with ACR≥300 mg/g （group A, n = 28）, a group with ACR〉30 mg/g〈 300 mg/g （group B, n = 31）, and a group with ACR≤30 mg/g （group C, n = 23）. Levels of ACR and Ang Ⅱ were determined by radioimmunoassay, and serum TGFβ1 by a sandwich ELISA. The left ventricular telediastolic internal diameter, interventricular septum diastolic, posterior wall thickness, left ventricular mass index and left ventricular ejection fraction were determined by M-B mode echocardiography. Results： TGFβ1 level was significantly higher in group A than in groups B and C（ P 〈 0.01）, and was also significantly different between group B and C（ P 〈 0.05）. TGFβ1 was directly related to ACR, Ang Ⅱ and LVMI, but not related to BMI or blood pressure. Conclusion： TGFβ1, a useful marker plays an important role in the occurrence and progression of hypertensive target organ damage.

关 键 词：高血压 转化生长因子Β 血管紧张素Ⅱ 微量白蛋白尿 左室肥厚 

分 类 号：R544.1[医药卫生—心血管疾病]