鱼腥草体外抗巨细胞病毒的实验研究  

An Experimental Study of the in vitro Anti-cytomegalovirus Effect of the Traditional Chinese Medicine Houttuynia

作　　者：王昕荣[1] 陈素华[1] 刘海智[1] 张心红[1] 邓群蓉[1] 陈莉[1] 邓东锐[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,武汉430030

出　　处：《医药导报》2007年第6期579-581,共3页Herald of Medicine

基　　金：国家自然科学基金资助项目(基金编号:39970769)

摘　　要：目的研究中药鱼腥草体外抗豚鼠巨细胞病毒的效果和安全性。方法以金叶败毒和更昔洛韦为对照药物,用细胞病变法和四甲基偶氮唑盐(MTT)法,检测鱼腥草抗豚鼠巨细胞病毒的最大无毒浓度、最小有效浓度和治疗指数。结果鱼腥草、金叶败毒和更昔洛韦的最大无毒浓度分别为30,3 mg.mL-1和100μg.mL-1,最小有效浓度分别为300,30和10μg.mL-1,治疗指数分别为100,100和10。结论中药鱼腥草在体外具有抗豚鼠巨细胞病毒的作用,且毒性较小。Objective To study the in vitro anti-cytomegalovirus effect of the traditional Chinese medicine houttuynia. Methods The maximum innocuity concentration（TD0）, minimum effective concentration（MEC） and therapeutic index（TI） of houttuynia in its anti-cytomegalovirus activity were detected with the cytopathic assay and MTT method. Jinyebaidu （JYBD） and ganciclovir were used as the control drugs. Results The TD0 of houttuynia, JYBD and ganciclovir were 30, 3 mg·mL^-1 and 100 μg·mL^-1, respectively,the MEC of the 3 drugs were 300,30 and 10 μg·mL^-1,respectively, and their therapeutic indices （TI） were 100,100 and 10, respectively . Conclusion The traditional Chinese medicine houttuynia was shown to be provided with an in vitro anti-cytomegalovirus effect with relatively low drug toxicity.

关 键 词：鱼腥草 巨细胞病毒 豚鼠 

分 类 号：R285[医药卫生—中药学] R978.7[医药卫生—中医学]