氧氟沙星-铝(Ⅲ)-十二烷基苯磺酸钠荧光体系测定氧氟沙星的研究  

Aluminium-Oxfloxacin-SDBS Fluorescence System for the Determination of Oxfloxacin

作　　者：马红燕[1] 齐广才[1] 陈小利[1] 张社争[1] 王平[1] 

机构地区：[1]延安大学化学与化工学院,陕西延安716000

出　　处：《分析测试学报》2007年第2期242-244,共3页Journal of Instrumental Analysis

基　　金：陕西省教育厅专项科研基金资助课题(04JK305)

摘　　要：在表面活性剂十二烷基苯磺酸钠（SDBS）存在下,氧氟沙星能与铝（Ⅲ）形成络合物而使氧氟沙星的内源性荧光显著增强,提出了氧氟沙星-铝（Ⅲ）-十二烷基苯磺酸钠（SDBS）荧光体系测定氧氟沙星含量的新方法.氧氟沙星在1.0×10^-9～2.0×10^-7 kg/L范围内,与荧光增敏值成良好的线性关系,方法检出限为5.0×10^-10 kg/L.该方法简单,灵敏度高,选择性好,可直接用于片剂和注射液中氧氟沙星含量的测定.A simple and sensitive fluorescence method for the determination of oxtloxacin was developed. It is based on the enhancement of endogenous fluorescence of oxfloxacin through forming a complex with aluminium（Ⅲ） in NaAc -HAc medium in the presence of sodium dodecyl benzene sulfonate（SDBS）. The experimental conditions influencing the fluorescence intensity were investigated and optimized. The linear range was 1.0×10^-9 - 2. 0×10^-7 kg/L with a detection limit of 5.0×10^-10 kg/L. This method was applied to the determination of trace oxfloxacin in tablets and injections with satisfactory resuits.

关 键 词：氧氟沙星 铝(Ⅲ) 十二烷基苯磺酸钠 荧光光度法 

分 类 号：O657.3[理学—分析化学] R97[理学—化学]