系统性红斑狼疮患者血清脂质水平与病情活动的相关分析  

Analysis of the Relationship between Lipid Profile and Disease Aactivity in Patients with Systemic Lupus Erythematosus

作　　者：方亮[1] 曾抗[1] 孙乐栋[1] 

机构地区：[1]南方医科大学南方医院皮肤科,广东广州510515

出　　处：《中国皮肤性病学杂志》2007年第5期280-282,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的评估未经治疗的系统性红斑狼疮(SLE)患者血清脂质水平,探讨其与SLE病情活动关系。方法分别检测38例未经治疗的SLE患者及30例健康查体者血清脂质水平,比较两组血清脂质水平的差异,并分析SLE患者组血清脂质水平与SLE患者病情活动的关系。结果未经治疗的SLE患者血清TG和VLDL水平较对照组增高,HDL水平较对照组降低。HDL水平与SLE疾病活动指数(SLEDAI)及ds-DNA滴度呈负相关,与补体C3和补体C4水平呈正相关。结论在未经治疗的SLE患者中,脂代谢异常已经存在,其中HDL与SLE病情活动密切相关。Objective To assess the lipid profiles in lupus erythematosus patients without any theapy , approach the relationship between lipid profile and disease activity in systemic lupus erythematosus patients. Methods Fasting blood samples taken from 38 patients of systemic lupus erythematosus （SLE） and 30 healthy controls were assessed for total cholesterol （TC）, triglyceride（TG）, high-density lipoprotein （HDL） and low-density lipoprotein （LDL） -cholesterol, and compared the results of the two teams, and analysis of the relationship between lipid profile and disease activity in systemic lupus erythematosus patients. Results A significant elevation of TG ,VLDL levels was observed in the SLE patients compared to that of controls（ P 〈 0.01 ）. The HDL level was also significantly lower in SLE patients than that of controls（ P 〈 0.01 ）. Moreover, HDL levels were found to be negatively correlated with SLEDAI scores and dsDNA tite, but positively to C3 and C4 levels of addiments. Conclusion Our findings show that SLE patients without any therapy have a lipid profile abnormality , and a significant correlation was found between SLEDAI scores and HDL levels.

关 键 词：红斑狼疮 系统性 血清脂质 SLE疾病活动指数 

分 类 号：R593.24[医药卫生—内科学]