近红外光谱范围人肝癌变和热凝固导致组织吸收和散射特性的变化  

Canceration and Thermal Coagulation of Human Liver Induced Changes in the Absorption and Scattering Properties of Liver-Tissue at NearInfrared in vitro

作　　者：魏华江[1] 邢达[1] 何博华[2] 谷怀民[1] 巫国勇[3] 陈雪梅[4] 鲁建军[3] 

机构地区：[1]华南师范大学激光生命科学研究所,激光生命科学教育部重点实验室,广东广州510631 [2]广东药学院临床医学系外科,广东广州510224 [3]中山大学第一附属医院心胸外科,广东广州510080 [4]中山大学第一附属医院眼科,广东广州510080

出　　处：《光谱学与光谱分析》2007年第5期868-872,共5页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金项目(60378043;30470494);广东省自然科学基金项目(015012;04010394);广东省科技计划项目(2004B10401011)资助

摘　　要：研究了人肝的癌变及热凝固导致其对710,730,750,770,790,810,830,850,870和890nm的钛宝石激光的吸收和散射特性的变化,实验采用双积分球测量系统以及反向倍增法获取肝组织的吸收和散射特性参数。结果表明人肝的癌变导致其吸收系数发生了显著的减小,其变化的最大值在850nm,其值为86.12%,而变化的最小值在750nm,其值为82.65%。正常人肝组织热凝固导致其吸收系数明显变化,其吸收系数的变化的最大值在710nm,其值为79.55%,而变化的最小值在790nm,其值为0.72%。人肝癌组织热凝固导致其吸收系数显著地增大,其变化的最大值在810nm,其值为78.69%,而变化的最小值在710nm,其值为38.16%。人肝的癌变导致了肝组织的散射系数发生了显著的增大,其变化的最大值在710nm,其值为158.37%,而变化的最小值在890nm,其值为136.03%。正常人肝组织热凝固导致其散射系数显著地增大,其变化的最大值在890nm,其值为632.92%,而变化的最小值在710nm,其值为587.40%。人肝癌组织热凝固导致其散射系数显著地增大,其变化的最大值在810nm,其值为384.25%,而变化的最小值在710nm,其值为330.86%。肝组织的吸收和散射特性的变化也随着激光波长的变化而变化。Canceration and thermal coagulation of human liver induced changes in the absorption and scattering properties of liver tissue at 710, 730, 750, 77, 790, 810, 830, 850, 870 and 890 nm of Ti： sapphire laser were studied in vitro. The measurements were performed using a double-integrating-sphere setup, and the absorption and scattering properties were assessed from these measurements using the inverse adding-doubling method. The results of measurement showed that canceration of liver induced significant decrease in the absorption coefficients of liver tissue, and the maximum change in the absorption coefficients is 86. 12% at 850 nm, while the minimum change in the absorption coefficients is 82.65% at 750 nm. Thermal coagulation of normal liver induced obvious change in the absorption coefficients from 710 to 890 nm, and the maximum change in the absorption coefficients is 79.55% at 710 nm, while the minimum change in the absorption coefficients 0. 72% at 790 nm. Thermal coagulation of carcinoma liver tissue induced significant increase in the absorption coefficients, the maximum change in the absorption coefficients of carcinoma liver tissue is 78. 69% at 810 nm, in the minimum change in the absorption coefficients of carcinoma liver tissue 38. 16% at 710 nm. Canceration of liver induced significant increase in the scattering coefficients of liver tissue, and the maximum change in the scattering coefficients is 158.37% at 710 nm, while the minimum change in the scattering coefficients is 136. 03% at 890 nm. Thermal coagulation of normal liver induced significant increase in the scattering coefficients of liver tissue, and the maximum change in the scattering coefficients is 632. 92% at 890 nm, while the minimum change for the scattering coefficients is 587.40% at 710 nm. Thermal coagulation of carcinoma liver tissue induced significant increase in the scattering coefficients, and the maximum change in the scattering coefficients of carcinoma liver tissue is 384. 25% at 810 nm, while the minimum change in the sca

关 键 词：人肝组织 吸收和散射特性 钛宝石激光 癌变 热凝固 

分 类 号：R318.5[医药卫生—生物医学工程]