新活素对急性心衰患者心率变异性的影响  

Effects of Lyophilized Recombinant Human Brain Natriuretic Peptide on Heart Rate Variability in Acute Decompensated Heart Failure

作　　者：张大勇[1] 李德才[1] 王庆旭[1] 刘思泰[1] 王永春[1] 唐焕君[1] 舒艳[1] 

机构地区：[1]川北医学院第二附属医院心内科,四川省绵阳市621000

出　　处：《实用全科医学》2007年第6期485-486,共2页Applied Journal Of General Practice

摘　　要：目的观察新活素——冻干重组人脑利钠肽(Lyophilized Recombinant Human Brain Natriuretic Peptide,Lrh-BNP)治疗急性失代偿心力衰竭(Acute decompensated heart failure,ADHF)对心脏自主神经功能的影响。方法对照组49例,进行基础抗心衰治疗;Lrh-BNP组45例,在基础抗心衰治疗上静脉注射Lrh-BNP 24 h。所有患者治疗前后均进行24 h Holter检查,对Lrh-BNP治疗前后及对照组进行心率功率谱时域和频域分析。结果Lrh-BNP组治疗后心率变异性(HRV)值较对照组显著改善,其中时域指标:全部正常R-R间期的标准差(SDNN)、每5 min R-R间期均值的标准差(SDANNI)、SDNN的均值(SDNNI)、正常相邻R-R间期差值的均方根RMSSD、正常相邻R-R间期差值>50 ms的百分比(PNN50)、心率均显著改善(P<0.05);频域指标:总频谱(TF)、低频(LF)和高频(HF)亦明显改善(P<0.05)。结论Lrh-BNP可改善ADHF患者的心率变异性。Objective To study the effect of lyophilized recombinant human brain natriuretic peptide （ Lrh-BNP ） on heart rate variability in acute decompensated heart failure （ADHF）. Methods Forty nine cases with ADHF were treated by routine measure （as control）. Forty five cases were treated with Lrh-BNP for 24 hours based on the routine measure. The heart rate power spectral density and time-domain were analyzed with 24 hour electrocardiographic monitoring before and after using Lrh-BNP. Results Compared with the control group,time-domain analysis in Lrh-BNP after the treatment revealed a significant improved in SDNN, SDANNI, SDNNI, RMSSD, PNN50 （ P 〈 0.05 ）. Heart Rate and frequency domain analysis revealed marked improve of total,low and high frequency components （P 〈 0.05 ）. Conclusions Lrh-BNP can significantly improve the heart rate variability in ADHF.

关 键 词：冻干重组人脑利钠 心力衰竭 心率变异性 

分 类 号：R541.6[医药卫生—心血管疾病]