制蚜菌素对大鼠的亚慢性经口毒性  

Study of Sub-Chronic Oral Toxicity of Biologic Pesticide Aphicidin in Rats

作　　者：朱丽秋[1] 陈琼姜[1] 顾刘金[1] 杨校华[1] 黄雅丽[1] 朱勇[1] 徐娟[1] 

机构地区：[1]浙江省医学科学院,杭州市310013

出　　处：《职业与健康》2007年第11期908-909,共2页Occupation and Health

摘　　要：目的研究制蚜菌素对SD大鼠的亚慢性经口毒性。方法按照GB 15670-1995《农药登记毒理学实验方法》,设为0.0、2.4、9.6、38.3 mg/kg饲料4个剂量组,每组20只大鼠,雌雄各半;分别采用无明显损害作用剂量(NOAEL)和基准剂量(BMD)计算亚慢性经口毒性阈值。结果大鼠亚慢性经口毒性试验显示,高、中剂量组肝重、肝脏器系数及摄食量低于对照组,差异有统计学意义,且均存在剂量-效应关系,呈负相关。结论制蚜菌素原药亚慢性经口毒性NOAEL雌雄性大鼠分别为(0.22±0.02)、(0.18±0.01)mg/(kg.d),BMD的95%可信限下限(BMDL)雌雄性大鼠分别为0.790、0.319 mg/(kg.d)。[ Objective] To study the sub- chronic oral toxicity of biologic pesticide aphicidin in rats. [ Methods] According to the GB 15670- 1995 ＂Toxicological Testing Methods for Pesticide Registration＂, four dose groups （0, 2.4, 9.6 and 38.3 mg/kg of feed） were established with 20 rats （10 males and 10 females） in each group; the sub -chronic toxicity threshold value was calculated using NOAEL and benchmark dose （ BMD ） respectively. [ Results] The liver weight, liver - body coefficient and total food consumption of the high and middle dose groups were lower than that of the control group, the difference indicated statistic significance and negative dose - effect correlations. [ Conclusion ] The NOEL of aphicidin sub - chronic toxicity were （ 0.18 ± 0.01 ） mg/（ kg. d） and （0. 22 ± 0. 02） mg/（ kg. d） among females and male rats respectively; the BMDs were 0.790mg/（kg.d） and 0. 319 mg/（ kg. d） among female and male rats respectively.

关 键 词：生物农药 制蚜菌素 亚慢性经口毒性 

分 类 号：R114[医药卫生—卫生毒理学]