心肌酶谱测定对新生儿缺氧缺血性脑病患者心肌损害的诊断价值  

Diagnostic value of myocardial enzyme in myocardial damage of neonatal hypoxic ischemic encephalopathy.

作　　者：黎小秀[1] 张兰[1] 朱樱梅[1] 

机构地区：[1]东莞市妇幼保健院,广东东莞523002

出　　处：《临床和实验医学杂志》2007年第5期33-34,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨心肌酶谱测定对新生儿缺氧缺血性脑病(HIE)患者心肌损害的诊断价值。方法将150例HIE患儿分轻、中、重度组与52例正常新生儿对照,测定血浆中天门冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)和α-羟丁酸脱氢酶(α-HBDH)的活性,常规心电图检查,并进行统计分析。结果HIE时血浆AST、LDH、CK、α-HBDH活性随着病情的加重而相应升高,尤以CK、CK-MB升高明显,与临床分度呈正相关。重度组较正常对照组明显升高,差异有显著性(P<0.01);HIE患儿心电图检查异常74例(50%),其中轻度组13例(29%),中度组28例(50%),重度组33例(69%)。结论监测患儿心肌酶谱的变化,能较好地协助临床早期诊断HIE时有无心肌损伤及损伤程度,对判断病情、估计预后具有重要的临床意义。Objective To evaluate the diagnostic value of myocardial enzyme determination in myocardial damage of neonatal hypoxic ischemic encephalopathy （HIE）. Methods 150 neonetes with HIE were ivided into three groups according to the degree of illness：mild, moderate and severe. Plasma myocardial enzyme determination, including AST, LDH, CK, CK - MB and α - HBDH and electrocardiogram were taken. Control group consisted of 52 normal neonates, Results The activity of AST, LDH, CK and α- HBDH increased with the severity of HIE, especially CK and CK - MB. Myocardial enzyme activity was correlated with the severity of HIE ; Myocardial enzyme activity was significantly higher in severe group than in control group（ P 〈0.01 ）. ECG was abnormal in 74 neonates （50%） with HIE, of which mild group 13 （29%）, moderate group 28 （50%） and severe group 33 （69%）. Conclusion Myocardial enzyme activity may help to determine whether there is myocardial damage in HIE and its severity. It is of great value to disease sevirity judgement and prognostic evaluation.

关 键 词：缺氧缺血性脑病 新生儿 心肌酶 心肌损害 

分 类 号：R722.1[医药卫生—儿科]