玉丹荣心丸抗急性病毒性心肌炎的实验研究  

Experimental Therapy of Acute Coxsackie Viral Myocarditis by Chinese Traditional Medicine-Yudan Rongxing Pill

作　　者：赵晶[1] 张中海[2] 刘剑[3] 孙艳[4] 钟照华[2] 

机构地区：[1]黑龙江省大庆市人民医院检验科 [2]哈尔滨医科大学微生物学教研室 [3]黑龙江省中医研究院哈尔滨 [4]齐齐哈尔医学院医学技术系

出　　处：《齐齐哈尔医学院学报》2007年第5期521-523,F0004,共4页Journal of Qiqihar Medical University

摘　　要：目的观察中成药玉丹荣心丸对B组柯萨奇病毒(CVB)感染Balb/c小鼠所致急性病毒性心肌炎的治疗效果的研究。方法Balb/c鼠腹腔接种1000 TCID50/0.1ml CVB,经过两周的持续注射成功获得急性病毒性心肌炎的动物模型。将动物随机分为病毒对照组、药物组,药物组使用中成药玉丹荣心丸进行灌胃给药,而病毒对照组不使用任何药物,28天后观察小鼠心肌组织的病理改变。结果药物组小鼠心肌组织的病理改变轻微,并有好转迹象,而病毒对照组病理改变严重,有死亡。结论玉丹荣心丸对B组柯萨奇病毒感染所致的急性病毒性心肌炎有很强的治疗效果。Objective To Observe the therapeutic effects of Yudan Rrongxing Pill （YDRXP）,the Chinese traditional medicine,against the acute myocarditis in Balh/c mice caused by Coxsackie virus B. Methods An acute viral myocarditis Balb/c model was prepared by inoculating 100 TCID50/0. lml of CVB3m for 2 weeks. The infected mice were then randomly divided into three groups：normal control, viral control, and YDRXW-treated. The YDRXP-treated group were orally given YDRXP. The viral control gave virus only. The myocardial pathology was observed after 28 days. Results The viral control mice could be found pathologically bad injured and dead, while the pathological manifestations in the YDRXP-treated mice were mild and suggested recovery trends. Conclusions Traditional Chinese medicine YDRXP can conduct a therapeutic effect to acute viral myocarditis caused by CVB.

关 键 词：玉丹荣心丸 病毒性心肌炎 B组柯萨奇病毒 小鼠 

分 类 号：R542.21[医药卫生—心血管疾病]