调脂灵对高脂血症大鼠脂代谢酶及载脂蛋白的影响  

Effects of Tiao Zhilin capsules(TZHL) on serum LPL,HL,ApoAⅠ and ApoB in hyperlipidemia rat model

作　　者：唐春萍[1] 郭姣[1] 杨超燕[1] 何伟[1] 袁安攀[1] 

机构地区：[1]广东药学院中药药理教研室,广东广州51006

出　　处：《广东药学院学报》2007年第2期175-177,共3页Academic Journal of Guangdong College of Pharmacy

基　　金：广东省科技计划项目(2005B30101018)

摘　　要：目的探讨调脂灵(TZHK)对高脂血症大鼠的调血脂作用和机理。方法采用大鼠喂食高脂乳剂建立高脂血症模型,观察调脂灵对高脂血症模型大鼠血脂水平、载脂蛋白AⅠ(ApoAⅠ)、载脂蛋白B(ApoB)含量及脂蛋白酯酶(LPL)、肝脂酶(HL)活性的影响。结果调脂灵的三个剂量组均能显著降低饮食性高脂血症模型大鼠血清中总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)、ApoB的水平,并能显著升高HDL-C、ApoAⅠ、LPL、HL水平。结论调脂灵具有调节血脂代谢异常作用,对高脂血症有防治作用。Objective To investigate the lipid -regulating effects and mechanism of Tiao Zhilin capsules （TZHL） on lipoprotein in blood in the hyperlipidemia rat model. Methods Experimental hyperlipidemia rats were formed after feeding fatty diet for 8 weeks, and the level of lipoprotein （ TG, TC, LDL-C, HDL-C ）, apolipoprotein （ ApoA Ⅰ, ApoB ）, LPL and HL in blood were observed. Results Administered with TZHL at low dose, intermediate dose, and high dose could obviously reduce the levels of TC, TG, LDL-C and ApoB, and also significantly increase the levels of HDL-C, LPL, HL and ApoA I in hyperlipemia rat. Conclusion TZHL could regulate the abnormal lipoprotein in blood and preventing hyperlipidemia.

关 键 词：调脂灵 脂代谢酶 载脂蛋白 高脂血症模型 

分 类 号：R285[医药卫生—中药学]