甲磺酸培氟沙星在山羊体内的药物动力学研究  

Studies on the Pharmacokinetics of Pefloxacine Mesylate in Goats

作　　者：谢沄[1] 李引乾[1] 杨亚军[1] 黄勇旗[1] 

机构地区：[1]西北农林科技大学动物科技学院,陕西杨凌712100

出　　处：《西北农业学报》2007年第3期29-32,共4页Acta Agriculturae Boreali-occidentalis Sinica

摘　　要：分析了甲磺酸培氟沙星(Pefloxacine Mesylate,PM)在成年山羊体内的代谢动力学过程。山羊单剂量快速静注PM10 mg/kg,8 h内不同时间14次颈静脉采血,用高效液相色谱法测定血药浓度。结果表明,PM在山羊体内的药物动力学配置符合无吸收因素二室开放模型。其药-时曲线最佳方程为:C=9.3680e-5.6806t+9.4885e-0.4393t;主要药物动力学参数:分布半衰期t1/2α=0.1678±0.1298 h,消除相半衰期t1/2β=1.6322±0.3189 h,药-时曲线下面积AUC=24.7542±6.4560μg.mL-1.h,表观分布容积Vd=0.9676±0.1498 L.kg-1,体清除率CLB=0.4219±0.0832 L.kg-1.h-1。结果显示PM在山羊体内分布迅速而广泛,消除较快。Pharmacokinetic parameters of Pefloxacine Mesylate （PM） in 6 goats were calculated. Goats were treated with a single dosage of PM （10 mg/kg） intravenously and rapidly, while the blood samples were collected from jugular vein within 8 hour after giving drug. The concentrations of PM in serum were determined by high performance liquid chromatography （HPLC）. The results showed that the two-compartment open model with first-order disabsorption factor adequately describes concentrations of PM in serum disposition and the best concentrationtime equations are： C= 9. 3680e^-5.6806t ＋ 9. 4885e-0.4393t. The primary pharmacokinetic parameters of PM are： t1/2α = （0. 1678±0. 1298）h, t1/2β =（1. 6322±0. 3189）h, AUC=（24. 7542±6. 4560）μg· mL^-1 · h, Vd=（0. 9676±0. 1498）L · kg^-1, CLB= （0. 4219±0. 0832）L · kg^-1· h^-1. It will be seen that the distribution of PM in vivo is rapid and abroad, and the elimination of PM in vivo is rapid.

关 键 词：甲磺酸培氟沙星 山羊 药物动力学 

分 类 号：S859.796[农业科学—临床兽医学]