变应性接触性皮炎与免疫耐受  

Allergic contact dermatitis and immunotolerance

作　　者：陈继莺[1] 王学民[2] 

机构地区：[1]上海同济大学医学院,200092 [2]上海市皮肤病性病医院

出　　处：《国际皮肤性病学杂志》2007年第3期180-182,共3页International Journal of Dermatology and Venereology

摘　　要：变应性接触性皮炎以T细胞介导的Ⅳ型变态反应为主，少部分也可表现为I型变态反应的迟发相。机体的免疫系统一方面对抗外来的病原体和致敏原，同时发挥调节功能，控制过强的免疫反应，临床出现免疫耐受。Ⅳ型变态反应的免疫调节基础是CD4^＋的T调节细胞，在变应性接触性皮炎中发挥调节作用的主要为1型T调节细胞和2型T调节细胞。T调节细胞已成为免疫治疗及其评价的分子标记之一。Allergic contact dermatitis （ ACD ） is induced mainly by type IV allergic reaction, partly by the late phase of type I allergic reaction. On the one hand, the body＇s immune system actively responses to exotic pathogens and allergens through immune reaction, while on the other hand, the system regulates the extent of the reaction and prevents body damage from it, and immunotolerance is developed in the latter process. The immunoregulation of type IV allergic reaction is mainly mediated by CD4^＋ T regulatory cells, and in ACD it is by Trl and Tr2 cells. T regulatory cells have become a molecular marker for immune therapy and evaluation.

关 键 词：皮炎 变应性接触性 免疫 免疫耐受 

分 类 号：R758[医药卫生—皮肤病学与性病学]