大肠癌染色体组DNA拷贝数异常的临床病理学意义  

Clinicopathologic significance of chromosomal DNA sequence copy number aberrations in patients with colorectal carcinoma

作　　者：刘秀萍[1] 河内茂人[2] 小贺厚德[2] 佐々木功典 

机构地区：[1]复旦大学上海医学院病理系,上海 200032 [2]日本山口大学医学院病理系

出　　处：《中华肿瘤杂志》2007年第5期355-359,共5页Chinese Journal of Oncology

摘　　要：目的分析大肠癌染色体组DNA拷贝数异常区域与患者临床病理特征的关系。方法应用比较基因组杂交技术（CGH）检测73例大肠癌患者的标本。结果大肠癌染色体8p12-pter丢失和8q23-qter扩增与淋巴结转移显著相关;而8q23-qter扩增和18q12-qter丢失与远处器官转移和（或）术后复发显著相关;8q23-qter扩增、8p12-pter和18q12-qter丢失,与大肠癌患者不良预后密切相关。Cox多因素分析表明,18q12-qter丢失在大肠癌是一个独立的不良预后生物学指标。结论采用CGH法检测染色体组DNA拷贝数异常能预测大肠癌患者的预后,并为临床治疗提供有意义的信息。Objective To analyze the correlation of DNA sequence copy number aberrations （DSCNAs）with clinicopathologic parameters in patients with colorectal cancer （CRC）. Methods Comparative genomic hybridization （CGH） method was used in analysis of 73 cases with CRC. Statistical analysis was performed using Stat View statistical software package（5.0）. Results Loss of 8p12-pter and gain of 8q23- qter were linked to nodal metastasis, while loss of 18q12-qter and gain of 8q23-qter were associated with distant organ metastasis at diagnosis and （or） recurrence after surgery. Moreover, losses of 8p12-pter and 18q12-qter and gain of 8q23-qter were associated significantly with unfavorable prognosis. Multivariate analysis revealed that loss of 18q12-qter was an independent prognostic marker. Conclusion Our findings indicate that genetic aberrations detected by CGH may predict outcome in patients with CRC, and may provide useful information for clinical treatment.

关 键 词：比较基因组杂交 结直肠肿瘤 DNA 染色体 

分 类 号：R686[医药卫生—骨科学]