N-氯乙酰基-N-异丙基-4-氯苯胺的合成研究  

Study on the Synthesis of N-chloroacetyl-N-isopropyl-4-Cloroaniline

作　　者：陈同明[1] 张迎芬[1] 宋静德 刘德全[1] 

机构地区：[1]江苏安邦电化有限公司,江苏淮安3556026

出　　处：《化工中间体》2007年第5期3-5,共3页

摘　　要：研究了N-氯乙酰基-N-异丙基-4-氯苯胺的制备工艺。以对硝基氯苯、丙酮为原料,复合钯/碳催化剂,1.0MPa压力下一步制得N-异丙基-4-氯苯胺,采用正交法确定了烷基化反应的优化的工艺条件。在优化的条件下,对氯硝基苯转化率99%,N-异丙基-4-氯苯胺选择性可达98%。对硝基氯苯经N-烷基化,N-酰氯化二步总收率92%,产品N-氯乙酰基-N-异丙基-4-氯苯胺纯度大于98%An improved method of preparing 4-cloro-N-isopropyl-N-chloro- acetylaniline from N-isopropyl-4-chloroaniline was introduced which was prepared in one step with 4-chlorobenzene and acetone as raw material and mixture of Pd/C as catalyst at pressure of 1.0MPa. The optimum reaction conditions were determined by orthogonal experiments.Then N- chloroacetyl-N-isopropyl-4-Cloro-aniline was synthesized through two steps of reaction i.e. N-alkylation, N-acylchloridation, the yied was 92%,the purity was higher than 98% under optimum reaction conditions.

关 键 词：N-氯乙酰基-N-异丙基-4-氯苯胺 N-异丙基-4-氯苯胺 烷基化 

分 类 号：TQ457.26[化学工程—农药化工]