血管生成素相关蛋白基因多态性与冠心病的关系  

The case-control study between angiopoietin-related gene 3(ANGPTL3) gene polymorphism and coronary heart disease(CHD)

作　　者：王延风[1] 常志文[1] 陈敬洲[2] 王曙霞[2] 傅春燕[2] 王虎[2] 惠汝太 

机构地区：[1]首都医科大学附属北京同仁医院干保科,北京100730 [2]中国协和医科大学阜外心血管病医院中德分子实验室

出　　处：《临床心血管病杂志》2007年第5期348-351,共4页Journal of Clinical Cardiology

基　　金：国家973项目资助(No:2006CB503805)

摘　　要：目的:研究中国人群血管生成素相关蛋白(ANGPTL3)基因单核苷酸多态性与冠心病的关系。方法:采用聚合酶链反应和限制性酶切的片段长度多态分析方法检测冠心病患者389例,健康人503例的AN-GPTL3基因+90782C/G多态性并统计各组的多态性频率。结果:冠心病亚组与对照组、冠心病心肌梗死组与对照组之间的基因型频率分布差异有统计学意义,C等位基因频率在冠心病组、冠心病心肌梗死亚组和对照组分别为49.6%、51.5%和41.6%(P<0.05)。结论:ANGPTL3基因rs1168013位点C/G多态性与中国人冠心病心肌梗死发病相关,ANGPTL3可能是冠心病发病的易感基因。Objective： To investigate the relationship between angiopoietin related gene 3 （ANGPTLI3） gene polymorphism and coronary heart disease（CHD） in Chinese population. Method： The technology of polymerase chain reaction-restriction fragment length polymorphism（PCR RFLP） was used to detect the frequency of ANGPTL3C/G genetype and allele. The cases included 389 CHD patients and 503 controls. Result： The frequency of ANGPTL3rs1168013 C/G genetype and allele had significant difference between CHD and control（P〈0.05）. The frequency of this polymorphism was consistent with the law of Hardy Weinberg. Conclusion： The C/G polymorphism of ANGPTL3 rs1168013 is likely involved in pathogenesis of myocardium infarction. It may be suggested that ANGPTL3 is closely related to CHD.

关 键 词：血管生成素相关蛋白 基因多态性 冠状动脉疾病 

分 类 号：R541.4[医药卫生—心血管疾病]