3种抗缺氧药物对筑路工人急进海拔4600m不同时间血红蛋白的影响  

Effects of Three Compound Anti-Hypoxic Drugs on Hemoglobin of Roadman Acute Exposed to 4 600m Altitudes

作　　者：陆保革 郭志坚 黄慧群 马宝林 陈斌 卓君联 徐小云 

机构地区：[1]青海省交通医院,810008

出　　处：《高原医学杂志》2007年第1期10-12,共3页Journal of High Altitude Medicine

摘　　要：目的：探讨三种抗缺氧药物对筑路工人急进高海拔地区不同时间血红蛋白的影响。方法：受试者随机分为服药组A组（复方1号）、B组（复方2号）、C组（复方3号）和对照组（D组），每组（23～24）人。启程时开始服药，每天早、中、晚各服药一次，连续服药3周。到达海拔4600m施工现场第1天、3天、7天、15天进行血红蛋白测定，与服药前血红蛋白比较。结果：进驻后第一天各组血红蛋白与服药前组内比较，差别有非常显著性（P〈0．01）；第15天复方2号组、安慰剂组与服药前组内比较，差别有显著性（P〈0．05）。第1天与第3天、第15天各组组内比较，差别有显著性（P〈0．05）；第一天与第7天比较，除复方2号组外其余各组组内比较，均差别有非常显著性（P〈0．01）；第3天与第15天复方1号组、复方3号组组内比较，差别有显著性（P〈0．05）。结论：三种抗缺氧药物均不同程度改善红细胞携氧功能，以复方1号、复方3号效果较好。Objective： To discuss the influences of three compound anti--hypoxic drugs on hemoglobin （Hb） of roadmen rapidly ascended to high altitudes at different time. Methods： The subjects were divided randomly into the group A , B ,C and the control group （Group D） of 22～23 persons each; the group A, B, C and D was taken the CoⅠ, CoⅡ, CoⅢ and placebo respectively （3 time/day） when they begun route until 3 weeks. The level of Hb was measured after arrive to the work--sites at the altitude of over 4,600 meters on the days 1, 3, 7 and 15. The results were compared with that before taking medicines. Results： There was a great difference （P〈0. 01） of HB between before and after the first exposed altitude day in each group; and a difference existed （P〈0. 05） among the 1st, third and 15th day in each group. Comparison of on dayl with on day 7 for HB had a significant difference （P〈0. 01） in each group but the group B. P〈0. 05 for comparison of HB between the day 3 and the dayl5 in the group A and group C. Conclusions： The Col, CoIl, ColII anti--hypoxic drugs can improve the function of carried oxygen in erythrocyte to varying degrees. Col and ColII drugs have preferable effects.

关 键 词：急进 高海拔 血红蛋白 缺氧 药物 疗效评价 

分 类 号：R96[医药卫生—药理学]