巴洛沙星生物黏附片的制备及体外释药考察  

Preparation and in vitro drug release evaluation of bio-adhesive balofloxacin tablets

作　　者：刘玲[1] 于香安[2] 

机构地区：[1]兰州大学药学院,甘肃兰州730000 [2]兰州大学第二医院国家药理基地,甘肃兰州730030

出　　处：《中国医院药学杂志》2007年第5期642-644,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:制备巴洛沙星生物黏附片,考察其体外释药行为,并测定其与大鼠离体胃、小肠组织的黏附力。方法:以羟丙基甲基纤维素(HPMCK15M)和甲壳胺(CS)为生物黏附材料和骨架材料,乳糖为稀释剂制备生物黏附片;以0.1mol.L-1盐酸溶液(pH3.0)500mL为溶剂,浆法(转速50r.min-1)测定2,8,18,24h时的释放度。以自制黏附力测定装置测定、比较巴洛沙星生物黏附片及巴洛沙星Ⅱ片对大鼠离体胃、小肠组织的黏附力。结果:巴洛沙星生物黏附片体外释放符合设计要求,其与大鼠离体胃、小肠组织的黏附力明显大于普通片,且与肠的黏附力大于与胃的黏附力。结论:该处方设计及制备工艺合理,能够满足设计要求。OBJECTIVE To prepare the bio-adhesive balofloxacin tablets and to compare the adhesion of the bio-adhesive balofloxacin tablets and balofloxacin tablets（Ⅱ） to the isolated stomach and the small intestine tissue of the rate. METHODS Hydroxypropyl methyl cellulose （HPMC） KOM and （CS） were used as the bio adhesive and binding materials in the research. Lactose was used as diluents in preparing the bio-adbesive balofloxain tablets. The dissolution of bio-adbesive balofloxain tab- lets and balofloxain tablets（Ⅱ） were deterrninated. Self-made adhesion device was used to measure and compare the adhesion of the bio-adbesive balofloxacin tablets and balofloxain tablets（Ⅱ） to the isolated stomach and the small intestine tissue of the rat. RESULTS The release behavior of the bio-adhesive balofloxacin tablets was in accord with the requirement of the design. The adhesion of the bio-adhesive balofloxacin tablets to isolated stomach and intestine tissue of the rat was obviously stronger than that of the common tablets, and the adhesion to the intestine was stronger than that to the stomach. CONCLUSION The bioadhesive tablets may meet the general requirements of the design.

关 键 词：巴洛沙星 生物黏附片 羟基甲基纤维素 

分 类 号：R944[医药卫生—药剂学]