中药有效成分研究与中药新药研发  

Active Ingredient Research on Chinese Materia Medica and Development of New Drugs of Chinese Materia Medica

作　　者：王海南[1] 

机构地区：[1]国家食品药品监督管理局药品审评中心,北京100038

出　　处：《中华中医药杂志》2007年第5期268-270,共3页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：对单味中药材中的有效成分进行研究,是中药现代化进程中一项不可或缺的工作。麻黄碱的提取揭开了我国研究常用中药有效成分的序幕,靛玉红、三氧化二砷治疗白血病及青蒿素治疗疟疾等的成功发现更是为世人瞩目。尽管中药有效成分的研究已经给新药研发带来若干佳绩,但现实却不容乐观,需要摆脱纯分析的观点,需要充分地进行活性筛选,需要坚持以复方为中药新药的研发主体,并善于有机把握“精确”与“模糊”。The study on the active ingredients of single Chinese crude drugs has the various values, and it is an indispensable process of the modernization of Chinese materia medica. Ephedrine extraction opened a prelude of the active ingredients commonly used Chinese materia medica in China, and the found of indirubin and arsenic trioxide for the treatment of leukemia and artemisinin for the treatment of malaria were the proud achievements. Although the research of active ingredients on Chinese materia medica has brought some success in the development of new drugs, the reality can not be too optimistic. It needs get rid of a purely analytic perspective, needs to carry out the activity screen sufficiently, needs to adhere to the main body of complex prescription in the development of new drugs of Chinese materia medica, and needs to grasp the ＂precise＂ and ＂ambiguous＂ organically.

关 键 词：中药 有效成分 新药 

分 类 号：R284[医药卫生—中药学]