15例健康成人肾上腺皮质、髓质形态定量分析  

Morphometric analysis on 15 adrenal glands of health adult human

作　　者：王威[1] 赵军[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院泌尿外科,武汉430022

出　　处：《临床泌尿外科杂志》2007年第5期361-363,共3页Journal of Clinical Urology

摘　　要：目的:通过对健康成人肾上腺皮质、髓质形态定量分析,计算正常肾上腺髓/皮质比,分析髓/皮质比在腺体不同部位的变化规律,为肾上腺髓质增生的病理定量诊断提供依据。方法:收集突发事件意外死亡的健康成人完整肾上腺15例,甲醛固定后沿其长轴均分为18段,分别包埋、切片及染色,运用计算机技术采集切片图像,并计算髓/皮质比。结果:正常成人肾上腺髓/皮质比为(0.122±0.020);髓/皮质比值从头至尾部先突然上升后逐渐下降,下降过程又表现为先急后缓,直至为零。结论:应用常规组织学与现代计算机技术,可计算正常肾上腺髓/皮质比值,为肾上腺髓质增生的病理定量诊断奠定基础。Objective：To measure adrenal medulla/cortex ratio by quantitative analysis of adrenal medulla and cortex from corpse of sudden death health adult and provide the evidence for the clinic pathological diagnosis of ad renal medullary hyperplasia. Methods： Fifteen adrenals were collected and fixed in 4% formaldehyde, and then were evenly cut into 18 blocks perpendicular to the long axis and embedded in paraffin in the same direction, the slices were cut out of the blocks and stained with haematoxylin and eosin （H＆.E）. All the slices were photographed and the medulla/cortex ratio was computed with image analyzer software. Results： The normal medulla/cortex ratio of the human adrenal gland is 0.122±0.020. From the head to the tail of the gland, the ratio increases at first and decreases suddenly at the point of about 6% of the gland and decreases slowly at the point of about 70%. Conclusions： The adrenal gland medulla/cortex ratio could be measured by the combination of modern computer technique and histology. It can establish a basis for the clinic pathological diagnosis of adrenal medullary hyperplasia.

关 键 词：肾上腺 形态定量 髓/皮质比 肾上腺髓质增生 

分 类 号：R322.5[医药卫生—人体解剖和组织胚胎学] R586[医药卫生—基础医学]