蛛网膜下腔药物灌注治疗对脊髓损伤后TXA_2/PGI_2变化的影响  

Effect of Intra arachroid Space Perfusion Therapy on Alteration of Thromboxane / Prostacycline following Spinal Cord Injury in Rabbits

作　　者：涂意辉[1] 杜靖远[1] 夏志道[1] 汪岚[1] 

机构地区：[1]同济医科大学附属协和医院骨科

出　　处：《中华创伤杂志》1997年第1期15-17,共3页Chinese Journal of Trauma

基　　金：国家自然科学基金

摘　　要：目的：研究蛛网膜下腔灌注地塞米松和维拉帕米对脊髓损伤（ＳＣＩ）后血栓素Ａ２（ＴＸＡ２）和前列腺素（ＰＧＩ２）变化的影响．方法：用Ａｌｅｎ法制作ＳＣＩ模型，放免法检测脊髓打击部位的ＴＸＢ２和６－酮－前列腺素Ｆ１α（６－Ｋｅｔｏ－ＰＧＦ１α）含量，同时行病理学检查．结果：药物灌注治疗显著降低了血栓素Ｂ２（ＴＸＢ２）含量和ＴＸＢ２／６－Ｋｅｔｏ－ＰＧＦ１α比值，使６－Ｋｅｔｏ－ＰＧＦ１α含量相对升高，并减轻了脊髓损伤程度．结论：蛛网膜下腔灌注地塞米松和维拉帕米治疗具有防止ＳＣＩ后ＴＸＡ２／ＰＧＩ２平衡紊乱作用，从而改善脊髓血流，促进神经功能的恢复．Aim: To study the effect of intra arachroid space dexamethasone and verapamil perfusion therapy on alteration of thromboxane A 2 / prostacycline following spinal cord injury in rabbits. Methods: TXB 2 and 6 Keto PGF 1α concentration in injured site were studied using a rabbit spinal cord injury model by Allen's weight drop method (12g×12cm), and were measured by radioimmunoassay. Pathological changes in injured site were studied. Results: In treatment of intra arachroid space dexamethasone and verapamil perfusion therapy, 6 Keto PGF 1α levels were increased significantly, TXB 2 /6 Keto PGF 1α ratio was reduced significantly. Pathological damage was lessened. Conclusion: Intra arachroid space dexamethasone and verapamil perfusion therapy protects spinal cord from inbalance of TXA 2/PGI 2, thereby it probably improves spinal cord blood flow and neurological recovery after spinal cord injury.

关 键 词：蛛网膜下腔 药物灌注 地塞米松 脊髓损伤 

分 类 号：R651.205[医药卫生—外科学] R971[医药卫生—临床医学]