习惯性流产患者丈夫精子核染色质状态评价  

The Evaluation of the Sperm Chromatin Status from Spouses of Women with Spontaneous Abortion

作　　者：魏育英[1] 任伟 朱继望[1] 常翠芳[1] 威玉才 刘子龙[1] 

机构地区：[1]同济医科大学计划生育研究所,武汉430030 [2]武汉科盾门诊部,武汉430010

出　　处：《同济医科大学学报》1997年第1期58-60,共3页Acta Universitatis Medicinae Tongji

摘　　要：对31例习惯性流产患者丈夫精液和35例具正常生育能力非习惯性流产者丈夫的精液进行质量检查分析，并对31例习惯性流产中的21例精液标本，进行了精子核吖啶橙诱发荣光检查.结果显示，两组间精液液化时间、pH值、精子密度、精子成活率、运动能力无明显差异;两组间异常精子百分率有明显差异（P＜0.01）;两组间发黄色荧光、红色荧光精子百分率有显著差异（P＜0.01）。结果提示，胚胎早期丢失的原因可能与精子核染色质异质性密切相关。Semen samples from husbands of women with habitual abortion (n= 31) and from normal fertile donors (n= 35) were subjected to conventional semen analysis, and acridine orange nuorescence was performed on 21 of 31 cases, no significant difference was detected between liquefaction time (min), pH, the sperm concentration (×109/L), sperm vital ratio (% ), and motility (%). However, the difference in abnormal sperm morphology of the two groups was significant (P＜0.01), and tbe difference in percentage of yellow fluorescence sperms and red fluorescence sperms was markedly significant (P＜0.01). The results suggest that the presence of the sperm chromatin heterogenity may lead to a result of early pregnancy loss.

关 键 词：吖啶橙试验 流产 习惯性流产 精子 染色质 

分 类 号：R714.210.2[医药卫生—妇产科学] R321.1[医药卫生—临床医学]