外源性睾酮对去势雄兔早期动脉硬化的作用  

The influence of exogenous testosterone on early atherosclerosis of coronary artery in castrated and cholesterol-fed male rabbits

作　　者：王蓉[1] 范利[1] 李小鹰[1] 武强[1] 

机构地区：[1]解放军总医院,北京100853

出　　处：《中华老年心脑血管病杂志》2007年第5期339-341,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的旨在研究外源性睾酮对去势高脂饮食雄性家兔早期动脉硬化的影响,希望能为雄激素在临床合理应用提供一定的理论依据。方法将30只雄性新西兰白兔随机分为3组:外源性睾酮组、生理水平组与对照组。制备高脂并不同睾酮水平的雄兔模型,12周处死后测定雄兔血脂、载脂蛋白水平;观察并测量冠状动脉及肾动脉的内膜厚度。结果外源性睾酮组血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇、载脂蛋白B明显高于对照组和生理水平组(P<0.01);外源性睾酮组冠状动脉早期动脉硬化的程度重于对照组和生理水平组(P<0.05)。结论补充高于生理剂量的外源性睾酮对于去势高脂饮食雄兔冠状动脉早期动脉硬化有促进作用。Objective To determine the influence of different levels of serum testosterone on early atheroosclerosis of coronary artery in castrated male rabbits fed with cholesterol-rich diet.Methods Thirty white adult New Zealand male rabbits were randomly assigned to the three groups： control group, physiological group, exogenous testosterone group. All animals were castrated （bilateral castration） and fed with cholesterol-rich diet. Serum total testosterone, estradiol, lipids and lipoproteins were analyzed after twelve weeks. Histological pictures of coronary and kidney arteries were observed and analyzed. Results Average serum TC, TG, LDL-C, apoB, LDL-C/HDL-C, apoB/apoA1 were higher in exogenous testosterone group than in control group and physiological group（ P 〈 0.01）. Histological analysis showed more intense changes of early atherosclerosis of coronary artery in exogenous testosterone group than in control group and physiological group（ P 〈 0.05）. Conclusion Supplement of higher than physiological dose of exogenous testosterone accelerated early atherosclerosis of coronary artery in castrated male rabbits fed with cholesterol-rich diet.

关 键 词：冠状动脉硬化 睾酮 睾丸切除术 雄激素类 兔 

分 类 号：R543[医药卫生—心血管疾病]