老年人N端B型利钠肽参考值范围的初步观察  

Initial study on a reference range of N-terminal probrain natriuretic peptide in healthy elderly individuals

作　　者：肖路延[1] 王萌[1] 唐志毅[1] 郭健[1] 

机构地区：[1]卫生部北京医院检验科,100730

出　　处：《中华老年医学杂志》2007年第5期367-369,共3页Chinese Journal of Geriatrics

摘　　要：目的观察60岁以上健康老年人N端B型利钠肽（NT-proBNP）水平的参考值范围。方法将107例健康老年人根据年龄、性别分组,空腹采血,采用电化学发光法测定其血清NT-proBNP水平,将结果进行统计分析,NT-proBNP的参考值取97．5%可信限的上限。结果老年人NT-proBNP水平随年龄增长而增高,70～92岁组为（92．3±60．8）μg/L显著高于60～69岁组的（59．6±35．1）μg/L,（P＜0．05）,其平均水平约是60～69岁组的1．5倍;老年女性NT-proBNP水平为（128．5±61．3）μg/L,显著高于老年男性的（78．5±39．7）μg/L（P＜0．05）。取第97．5百分位数为参等值上限,老年男性为202．5μg/L,老年女性为319．3μg/L。结论NT-proBNP水平与受试者年龄、性别、种族等生理因素密切相关。各临床实验室应根据受试者不同年龄、性别分别建立实验室内NT-proBNP的参考值范围。Objective To establish a reference range of N-terminal probrain natriuretic peptide （NT-proBNP） for elderly healthy person. Methods A total of 107 elderly healthy subjects were enrolled in the study. Serum NT-proBNP level was determined by an automated electrocbemiluminescence immunoassay. The reference upper limit was defined by 97.5% confidence interval （CI）. Results Serum NT-proBNP level was increased with aging, and 1.5 times higher in ≥70 years old group[（92.3±60.8） μg/L] than in 60 69 years old group[（59.6±35.1） μg/L, （P〈0.05）3. Compared with elderly men [（78.5 ± 39.7）μg/L3, elderly women bad higher NT proBNP level [（128.5±61.3）μg/L3. The upper limit 97.5% CIof median was 202.5 μg/L for elderly men, 319.3 μg/L for elderly women. Conclusions NT-proBNP level is related with age, sex and race, and the clinical laboratory should establish its own reference range.

关 键 词：促尿钠排泄肽类 参考值 

分 类 号：R686[医药卫生—骨科学]