一种新的栓塞用平阳霉素明胶微球的制备  

Preparation of a new kind of gelatin-PYM-microspheres for arterial embolization

作　　者：邱麟[1] 封兴华[1] 吴红[2] 丁媛媛[3] 

机构地区：[1]西安第四军医大学口腔医院颌面外科,710032 [2]第四军医大学药学系化学教研室 [3]第四军医大学药学系药物研究所

出　　处：《实用口腔医学杂志》2007年第3期345-348,共4页Journal of Practical Stomatology

摘　　要：目的:选择一种新的交联剂制备栓塞用平阳霉素明胶微球。方法:分别以氧化葡聚糖和戊二醛作为交联剂制备2种注射用盐酸平阳霉素(PYM)明胶微球,比较2种微球形态学及生物学特性。结果:光镜下葡聚糖组微球的圆整度均优于戊二醛组;图像分析结果显示2组微球的粒径均符合栓塞用微球的要求;与戊二醛组相比,氧化葡聚糖组的粒径分布范围较窄(P<0.05);包封率、载药率(94.6%、8.9%)均高于戊二醛组(80.1%、5.5%),具有显著差异(P<0.05);且6h的累积释放率(71%)低于戊二醛组(91%),释药缓慢。结论:氧化葡聚糖作为一种新的交联剂具有更突出的优点。Objective：To choose a new crosslinking agent to prepare gelatin-Pingyangmycin（PYM）-microspheres for the interventional chemoemoblization therapy, nethods：Oxidized-dextran and glutaraldehyde were used respectively as crosslinking agent to prepare two kinds of gelatin-PYM-microspheres. The characteristics of prepared microspheres with different crosslinking agents were compared. Results：The roundness of oxidized-dextran group is better than glutaraldehyde group through optical microscope observation; and the distribution range of particle diameter of the two kinds of microspheres were fit for the use of embolization. However, oxidized-dextran group was with a narrower size distribution when compared with glutaraldehyde group（ P 〈 0.05 ） ; the drug content rate and the encapsulation rate of oxidized-dextran group were 94.6%, 8.9% respectively, which were higher than glutaraldehyde group, whose data were 80.1% , 5.5% （ P 〈0.05 ） ; the cumulative release rate of PYM from oxidized-dextran group in 6 hours was 71%, which was lower than glutaraldehyde group 95% （ P 〈 0.05 ）. Conclusion： These results implied the oxidized-dextran as a new kind of crosslinking agent has more advantages than glutaraldehyde.

关 键 词：明胶 氧化葡聚糖 微球 平阳霉素 

分 类 号：R943[医药卫生—药剂学]