灵芪胶囊对H_(22)荷瘤小鼠外周血IL-6含量的影响  

Effect of Lingqi Capsule on the Content of IL-6 in Peripheral Blood of Mice Bearing H_(22)

作　　者：肖佳音[1] 苏云明[1] 王文凯[1] 王宏婷[1] 佟欣[1] 李厚忠[1] 

机构地区：[1]黑龙江中医药大学,哈尔滨150040

出　　处：《中国药师》2007年第6期518-520,共3页China Pharmacist

基　　金：黑龙江省科技攻关项目中医药大学校基金重大项目(编号200503)

摘　　要：目的:观察灵芪胶囊对H_(22)荷瘤小鼠肿瘤的抑制作用,分析其抗肿瘤作用机制。方法:实验用昆明种小鼠接种H_(22)瘤株,经口灌胃灵芪胶囊和复方环磷酰胺11d后,取瘤体称重,计算抑瘤率,并计算免疫器官指数;采用双抗夹心ELISA法检测H_(22)荷瘤小鼠外周血IL-6含量。结果:灵芪胶囊在明显抑制肿瘤生长的同时不降低体重,在一定剂量下对荷瘤小鼠的免疫器官指数无明显影响,并能够明显抑制荷瘤小鼠外周血IL-6异常增高。结论:灵芪胶囊对H_(22)荷瘤小鼠有明显抑瘤作用,通过改善荷瘤小鼠异常的免疫状态。达到治疗肿瘤的目的。Objective： To discuss the anti-tumor effect of Lingqi capsule on mice bearing H22 and further explore the mechanism of action. Method： The model of H22 tumor-bearing mice was produced and treated with Lingqi capsule and Compound Cyclohosphamide Tablets. After giving drugs for 11 days,the inhibiting rate of tumor,thymus index,spleen index were calculated and the content of IL-6 in its peripheral blood was determined by ELISA. Result： Lingqi capsule obviously inhibits tumor without losing weight and influencing immune organs. Compared with the model group, the content of IL-6 was reduced significantly in peripheral blood. Conclusion ： Lingqi capsule can obviously inhibit tumor of H22. The mechanism may be related with improving abnormal state of immune of the mice with tumor.

关 键 词：灵芪胶囊 抗肿瘤 IL-6 

分 类 号：R285.5[医药卫生—中药学]