重视儿童2型糖尿病的临床研究  

Pay attention to the clinical research of T2DM in children and adolescents

作　　者：巩纯秀[1] 颜纯[1] 

机构地区：[1]首都医科大学附属北京儿童医院,100045

出　　处：《中国糖尿病杂志》2007年第5期260-262,共3页Chinese Journal of Diabetes

基　　金：首都医学发展科研基金资助项目(2002-2005);北京市科委课题资助项目(H030930030430)

摘　　要：很多国家和地区发现儿童糖尿病中的2型糖尿病(T2DM)比例逐年增加,但我国儿童T2DM患病率调查报道较少。国内外所报道的患病率差异,除了受地区、种族、经济状况等影响外,还与调查方法、年龄段、敏感性和特异性不同有关,但总的结果是儿童以青春期女性多发。此外儿童T2DM的概念以及病理生理的相关信息均来自成人的研究,国外有研究认为儿童T2DM以胰岛素分泌缺陷为主,与成人T2DM以胰岛素抵抗为主有一定差异。而且儿童T2DM的治疗基本是参考成人方案,但其治疗建议应严格分级。儿童T2DM的患病率、诊断和治疗还存在不少问题,有待进一步研究。It is well known that type 2 diabetes in children and adolescents is increasing in many countries or areas in recent years, while the reports on the issue are rare in China. There are great differences in the prevalence among different domestic and overseas reports just because of the different survey methods, such as incidence or prevalence, sensitivity or specificity, wider or narrow age group, and so on, except for the affects of different groups of age, area, race, and economic conditions. But in common, T2DM in children and adolescents is often in predilection in puberty girls. On the other hand, the concept and pathological information are from adult T2DM research. On the basis of very rare research, insulin secreting impairment is a key point in children, while insulin resistance is a main problem in adult T2DM. At last, the therapeutic regimens in children are from adult too and they are not graded strictly, and thus are not fit for children. The diagnosis and treatment in T2DM in children have many problems to be further researched in a long way.

关 键 词：糖尿病 2型 儿童 

分 类 号：R725.8[医药卫生—儿科]