瓜环[2]准轮烷分子晶体结构及切割DNA研究  

Crystal Structure and DNA Cleavage of [2]Pseudorotaxane Composed of Cucurbit[6]uril

作　　者：霍方俊[1] 阴彩霞[1] 杨频[1] 

机构地区：[1]山西大学分子科学研究所化学生物学与分子工程教育部重点实验室,太原030006

出　　处：《高等学校化学学报》2007年第5期894-896,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:30470408)资助.

摘　　要：The [2] pseudorotaxane of cucurbit[6]uril(CB[6]) with guest molecule 1,6-bis(imidazol-1-yl)hexane dihydrochloride(BIMH-Cl) made pBR322 DNA hydrolyzed efficiently in physiological environment. The cleavage mechanism was proposed that was a cooperation process of the CB[6] molecule and the guest BIMH molecule. In this mechanism, the protonated imidazole might bind DNA via the electrostatic interactions and the CB[6] glycoluril carbonyl oxygen atoms activated a water molecule to attack the phosphorus atom.The [ 2 ] pseudorotaxane of cucurbit [ 6 ] uril （ CB [ 6 ] ） with guest molecule 1,6-bis （ imidazol- 1 -yl） hexane dihydrochloride（BIMH-Cl） made pBR322 DNA hydrolyzed efficiently in physiological environment. The cleavage mechanism was proposed that was a cooperation process of the CB [ 6 ] molecule and the guest BIMH molecule. In this mechanism, the protonated imidazole might bind DNA via the electrostatic interactions and the CB [ 6 ] glycoluril carbonyl oxygen atoms activated a water molecule to attack the phosphorus atom.

关 键 词：瓜环 准轮烷 晶体结构 DNA切割 

分 类 号：O629.7[理学—有机化学]