五痹胶囊对系统性硬皮病患者免疫功能的影响  

Effect of Wubi Capsules on immune function in patients with systemic scleroderma

作　　者：李桂 王晓军 李学增 贾凤新 韩聚芳 钮含春 

机构地区：[1]河北省石家庄平安医院,河北050021

出　　处：《北京中医药大学学报》2007年第5期350-353,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：河北省科技攻关项目(No.03146493A)

摘　　要：目的研究五痹胶囊对系统性硬皮病(SSc)患者免疫功能的影响,并进一步探讨该复方中药抗SSc的作用机理。方法65例SSc患者随机分为治疗组33例、对照组32例。从T细胞亚群(CD3^+、CD4^+、CD8^+、CD4^+／CD8^+)变化、免疫球蛋白(IgG、IgA、IgM)含量、补体(C_3、C_4)水平、血浆内皮素(ET)、转化生长因子-β_1(TGF-β_1)的含量变化等方面进行前瞻性对比治疗研究,并与15例健康人群做比较。结果SSc患者T细胞亚群比例失调,免疫球蛋白(IgG、IgA、IgM)含量升高、补体(C_3、C_4)水平降低、血浆内皮素(ET)、转化生长因子-β_1(TGF-β_1)的含量明显升高。与健康人群比较差异有显著性(P＜0.05及P＜0.01),治疗后各组观察指标均有不同程度的降低,与治疗前比较有显著性差异(P＜0.05及P＜0.01)。治疗后治疗组与对照组比较,差异有显著性(P＜0.05及P＜0.01)。结论SSc患者免疫调节功能失常,自身抗体增加,免疫复合物积聚。五痹胶囊可纠正SSc患者免疫功能失调状态,提高机体的免疫自稳功能,清除抗原、抑制抗体产生,减少免疫复合物形成,降低ET、TGF-β_1的含量。说明五痹胶囊对SSc患者的预后影响与提高辅助性T细胞的功能、降低免疫球蛋白水平、升高补体水平、降低ET、TGF-β_1的含量有关。Objective To study the effect of Wubi Capsules on immune function in patients with systemic scleroderma（SSc） and its mechanism of action. Methods 93 SSc patients were randomly divided into treatment group （33 cases） and control group （32 cases ）. The patient＇s T lymphocyte subpopulation （CD3 ^＋ , CD4 ^＋ , CD8 ^＋ , CD5＋/CD8 ^＋ ）, immunoglobulin （ IgG, IgA, IgM ） , complement （ C3, C4 ）, plasma endothelin （ ET）, and transforming growth factor-β （ TGF-β） were prospectively and contrastively analyzed and compared with those of the 15 cases of healthy person. Results Patients with SSc showed disorder of T lymphocyte subsets. Compared with the healthy persons, immunoglobulins （ IgG , IgA , IgM）, ET and TGF-β were increased and complement level was decreased significantly （P 〈 0.05 ,P 〈 0.01 ）. There were significant improvements in above aspects in both groups after treatment（P 〈0.05, P 〈0.01 ）. Compared with the control group, the treatment group showed better effects, and there was significant difference between the two groups （ P 〈 0.05, P 〈 0.01 ）. Conclusion Patients with SSc show abnormal immunoregulation, high autoantibody and immunocomplex accumulating. Wubi Capsules can correct the state of abnormal immunoregulation in patients with SSc , increase the function of immune homeostasis, eliminate antigen, suppress antibody production, lessen the formation of immune complex, and decrease the content of ET and TGF-β. Wubi Capsules can influence prognosis of patients with SSc, which is related with suppressing Th＇ function and improving above mentioned indexes.

关 键 词：系统性硬皮病 免疫功能 五痹胶囊 

分 类 号：R259.932[医药卫生—中西医结合]