凝血因子基因多态性与深静脉血栓形成的相关性探讨  

Discussion on correlation between coagulation factors polymorphisms and deep venous thrombosis

作　　者：贺颖[1] 杨冬之[1] 于海东[1] 连建华[1] 郑红[1] 董子明[1] 

机构地区：[1]郑州大学基础医学院,河南郑州450052

出　　处：《山东医药》2007年第14期11-13,共3页Shandong Medical Journal

基　　金：河南省高校杰出人才刨新工程项目(2005KYCX020);河南省杰出青年科学基金项目(0612001300)。

摘　　要：目的探讨凝血因子基因多态性与深静脉血栓形成(DVT)的相关性。方法采用PCR-RFLP法对103例DVT患者(观察组)和250例健康人(对照组)进行FⅡ／G20210A、FⅦ／R353Q、F■／Val34LeuFⅦ基因多态性检测,并对基因型频率与等位基因频率作对比分析。结果观察组与对照组FⅡ／G20210A、FⅦ／R353Q、F ■／Val34Leu的基因型频率及等位基因频率差异无统计学意义,三种基因型频率的分布均符合Hardy-Weinberg平衡定律。结论FⅡ／G20210A、FⅦ／R353Q基因多态性可能不是深静脉血栓形成发病的遗传学风险因子;F■／Val34Leu多态性可能不是深静脉血栓形成发病的遗传保护因子。三种基因多态性均存在种族和地域差异。[Objective] To study the correlation between coagulation factors F I/G20210A,FⅦ/R353Q , F /Val34Leu polymorphisms and deep venous thrombosis. [Methods] 103 cases with deep venous thrombosis （patient groups） and 250 healthy subjects （control groups） were recruited in the study. The polymorphisms of F I /G20210A,FⅦ/R353Q and F /Va134Leu were detected by PCR-RFLP. Compared the genotype frequencies and allele frequencies. [Results] There were no significant differences in the genotype frequencies and allele frequencies of F I/G20210A,FⅦ/R353Q and F /Va134Leu polymorphisms between the cases of control＇group and control group. The genotype frequency distributions of three polymorphisms were in accordance with Hardy- Weinberg equilibrium. [Conclusions] Maybe the polymorphisms of F Ⅱ/G20210A and F I4[/R353Q are not the genetically risk factors of deep venous thrombosis. The F /Va134Leu polymorphism may be not a protective genetic factor against deep venous thrombosis. The prevalence of gene variants of F I/G20210A,FⅡ/R353Q and FⅦ/Va134Leu might have different ethnic background and geographical distribution.

关 键 词：F/Val34Leu FⅦ/R353Q 血栓形成 病因学 基因多态性 

分 类 号：R593.2[医药卫生—内科学]