2型糖尿病患者血清TNF-α、sTNFRI水平及与ESR相关性的研究  

Study on the serum levels of TNF-α and sTNFRI and their correlation with ESR in type 2 diabetes mellitus

作　　者：张静[1] 张景萍[1] 张瑞丽[1] 张开明[1] 

机构地区：[1]太原市中心医院,山西太原030009

出　　处：《检验医学》2007年第3期332-334,共3页Laboratory Medicine

基　　金：太原市科技局资助项目(20030313)

摘　　要：目的探讨2型糖尿病(T2DM)血清肿瘤坏死因子-α(TNF-α)、可溶性肿瘤坏死因子受体Ⅰ(sTN-FRI)水平及与红细胞沉降率(ESR)的相关性。方法严格选取32例T2DM患者及32名正常人为研究对象,采用酶联免疫吸附试验(ELISA)分别测定血清TNF-α和sTNFRI水平,采用魏氏法测定ESR。结果T2DM患者血清TNF-α、sTNFRI水平及ESR值均显著高于正常对照组,且血清TNF-α、sTNFRI水平与ESR值均具有相关性。结论TNF-α及sTNFRI与T2DM患者的炎性反应有关。Objective To analyze the serum levels of tumor necrosis factor-α （TNF-α ） and the soluble tumour necrosises factor receptor I （sTNFRI） in type 2 diabetes mellitus （T2DM） and their relationship with erythrocyte sedimentation rate （ESR）. Methods The serum levels of TNF-α and sTNFR1 were determined in 32 healthy subjects and 32 T2DM patients by enzvme-linked immunosorbent assay （ELISA） and ESR was determined by Westergren method. Restilts The serum TNF-α , sTNFR1 levels and ESR in T2DM patients were higher than that in normal controIs. The serum levels of TNF-α , sTNFRI correlated with ESR. Conclusions TNF-α and sTNFRI play an immporlant role in the pathogenesis of T2DM.

关 键 词：2型糖尿病 肿瘤坏死因子-Α 可溶性肿瘤坏死因子受体Ⅰ 红细胞沉降率 

分 类 号：R446.62[医药卫生—诊断学]