Catalytic Hydrogenation of α,β-Epoxyketones to β-Hydroxyketones with Two Sulfinyl Analogues of Coenzyme NADH Models  

作　　者：谢昆 崔毅 刘有成 傅尧 

机构地区：[1]Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China [2]College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China

出　　处：《Chinese Journal of Chemistry》2007年第6期839-842,共4页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （No. 20072036） and the Specialized Research Fund for the Doctoral Program of Higher Education of China.Acknowledgment We would like to thank Professor Yun-Dong Wu of the Hong Kong University of Science and Technology and Peking University for helpful advice.

摘　　要：An efficient method for the selective hydrogenation of a series of α,β-epoxyketones to β-hydroxyketones using catalytic amount of two sulfinyl analogues of NAD^＋ model compounds is reported. The lack of any diastereoselectivity for the formation of β-hydroxyketones with optically pure sulfinyl analogue of NAD^＋ model supports the radical mechanism proposed previously.An efficient method for the selective hydrogenation of a series of α,β-epoxyketones to β-hydroxyketones using catalytic amount of two sulfinyl analogues of NAD^＋ model compounds is reported. The lack of any diastereoselectivity for the formation of β-hydroxyketones with optically pure sulfinyl analogue of NAD^＋ model supports the radical mechanism proposed previously.

关 键 词：Coenzyme NADH model catalytic hydrogenation α β-epoxyketones 

分 类 号：O623.56[理学—有机化学]