溃疡性结肠炎时一氧化氮和超氧化物歧化酶变化及益生菌对其影响机制  

The levels of nitric oxide and superoxide dismutase in serum and intestine mucosal of ulcerative colitis and the influencing of probiotics agents to them

作　　者：刘建生[1] 田怡[1] 张晓红[1] 刘进[1] 马铭[1] 袁耀宗[2] 林健[3] 

机构地区：[1]上海瑞金医院集团闵行医院消化科,201100 [2]上海交通大学医学院附属瑞金医院消化科 [3]上海交通大学医学院生化教研室

出　　处：《中国医师进修杂志（内科版）》2007年第6期20-22,共3页Chinese Journal of Postgraduates of Medicine

基　　金：上海市科学技术委员会科研计划资助项目（044119751）

摘　　要：目的研究溃疡性结肠炎（UC）时一氧化氮（NO）和超氧化物歧化酶（SOD）的变化及益生菌（复合乳酸菌胶囊）对其的影响，探讨益生菌治疗UC的疗效。方法UC患者81例随机分为A组41例和B组40例。A组给予常规治疗＋复合乳酸菌胶囊，B组仅给予常规治疗。比较两组治疗前后血清、肠黏膜中NO和SOD的变化，并对两组患者临床症状改善情况、结肠镜检查情况和住院天数进行比较。另选择同时期行结肠镜检查无异常发现且机体无器质性病变者20例（C组）作为对照。结果A、B两组患者治疗前血清、肠黏膜中NO增高、SOD减少，与C组比较，差异有统计学意义（P〈0．01）。治疗后A组血清、肠黏膜中NO和SOD与B组比较，差异有统计学意义（P〈0．01），且临床症状改善率、肠黏膜征象改善率和住院天数也明显优于B组（P〈0．01）。结论UC患者血清、肠黏膜中NO和SOD异常，可能是UC发生和发展的主要因素之一；益生菌治疗UC有效，其机制与其调整肠道微生态和免疫功能、抑制NO及氧自由基产生有关。Objective To explore the changes of nitric oxide （NO） and superoxide dismutase （SOD） in the serum and intestine mucosal and the treatment of ulcerative colitis（UC） with probiotics agents. Methods Eighty -one patients with UC were randomly divided into treatment group（ group A, n = 41 ）and routine treatment group（ group B,n = 40 ）. Patients in the group A were given polylactone and routine treatment. Patients in the group B were only given routine treatment. The levels of NO and SOD were measured in all patients before and after the treatment. The clinical symptom, enteroscopy and hospital day were compared in the patients of the two groups. Twenty normal healthy controls（ group C） were involved in the study. Results The levels of NO in the serum and intestine mucosal were significantly increased and the levels of SOD were decreased in the patients of group A and group B compared with group C before treatment（P 〈0.01 ）. The levels of NO and SOD in the serum and intestine mucosal were recovered after the treatment in the patients of group A were superior to those of group B（P 〈 0.01 ）. The clinical symptom recovery rate, intestine mucosal symptom recovery rate and the days in hospital were all superior to those of group B（P 〈 0.01 ）. Conclusion The abnormal levels of NO and SOD in serum and intestine mucosal may play an important role in the development of UC. Probiotics agent is effective in the treatment of UC by the antagonism of NO and SOD.

关 键 词：溃疡性结肠炎 一氧化氮 超氧化物歧化酶 益生菌 

分 类 号：R285.5[医药卫生—中药学]