聚乙二醇对不同粒度羟基磷灰石的表面修饰  

SURFACE MODIFICATION OF DIFFERENT SIZED HYDROXYAPATITE BY POLYETHYLENE GLYCOL

作　　者：邓迟[1] 陈清宇[2] 姚宁[2] 卢雄[2] 周绍兵[2] 屈树新[2] 翁杰[2] 

机构地区：[1]乐山师范学院,四川乐山614004 [2]西南交通大学材料科学与工程材料先进技术教育部重点实验室,成都610031

出　　处：《硅酸盐学报》2007年第6期683-686,共4页Journal of The Chinese Ceramic Society

基　　金：教育部"跨世纪优秀人才培养计划"基金[(2002)48]资助项目

摘　　要：将聚乙二醇(polyethylene glycol,PEG)聚合物分别溶于含微米级的羟基磷灰石(micro-sized hydroxyapatite,m-HA)及纳米级的羟基磷灰石(nano-sized hydroxyapatite,n-HA)颗粒的水溶胶中,均匀分散后水洗,经冷冻干燥分别获得不同粒度的改性粉体。红外光谱分析显示:改性处理后2种粒度的HA粉体都含有PEG修饰剂。热重分析表明:经过800℃处理的n-HA粉体含有质量分数为3.05%的PEG,比同样改性处理的m-HA的少。X射线衍射分析表明:相转化前的低温煅烧过程中,大量能量用于PEG与HA的解吸。透射电镜的结果表明:PEG改性处理没有改变n-HA的尺寸和形貌。将PEG加入HA水溶胶中,它的亲水特性导致其分子链有序排列,其醚键与H2O和HA分子中的—H活性基团发生作用的机会均等,形成较弱的氢键结合。n-HA比m-HA的表面活性大,与水分子的结合更为紧密,在水溶胶中形成的网络结构更牢固,致使PEG在n-HA水溶胶中与HA形成的氢键减弱,PEG对n-HA表面修饰作用的效果比m-HA的差。Polyethylene glycol （PEG） was selected to coat nano-sized hydroxyapatite （n-HA） and micro-sized hydroxyapatite （m-HA） particles to investigate effects of the PEG on surface modification of different sized HA particles. Nano-sized and micro-sized HA powders were obtained by the freezing and spraying dry, respectively, after slurries with the HA particles and the PEG were vigorously stirred overnight and washed with distilled water. Infrared spectroscopy of the two HA powders shows that PEG appears on surfaces of these nano-sized and micro-sized HA particles. The thermogravimetric curves reveal that the mass of the PEG-coated micro-HA was more than that of the n-HA, which is 3.05% in mass. X-ray diffraction patterns of PEG-n-HA calcined at 800 ~C indicate that a large amount of heat energy is employed to desorb the PEG and n-HA. Transmission electronic microscope photographs reveal that PEG-n-HA have the same scale and morphology as the n-HA. Hydrogen bonding between molecules of the HA and PEG is the main adsorptive force allowing the PEG to coat the surface of the HA particles. As the dimensions of the HA particles increase, hydrogen bonding between the HA molecules become weaker, which facilitates the PEG adhesion on the surface of the HA. Therefore, the bonding strength between the n-HA and the PEG molecules is less than between the m-HA and the PEG Because the surface energy is higher for the n-HA particles than for the m-HA, the n-HA particles are more likely than the m-HA particles to absorb water molecules, so the PEG forms weaker bonds with the n-HA particles than with the m-HA particles in water sol. These results and discussion suggest that the PEG is more effective on the m-HA particles.

关 键 词：羟基磷灰石 修饰作用 聚乙二醇 

分 类 号：R318.08[医药卫生—生物医学工程]