肝移植后肝脏病理学及功能变化的实验研究  

The Experimental Research of Liver Pathological and Functional Changes After Living Transplantation

作　　者：田明祥[1] 王红鲜[1] 王跃全[1] 张培建[1] 金成[1] 周斌[1] 张淼[1] 

机构地区：[1]扬州大学第二临床医学院普通外科研究室,江苏扬州225001

出　　处：《实用临床医药杂志》2007年第3期40-44,共5页Journal of Clinical Medicine in Practice

基　　金：江苏省科技厅社会发展科技计划项目(BS2005038)

摘　　要：目的研究同基因大鼠肝移植后移植物的组织学和功能变化规律。方法将51只受体随机分为A、B、C 3组,每组17只,分别在术后第2、7、14天处死,取肝脏标本显微镜下观察;取血检测TB、ALT、GGT。结果A组肝细胞变性、坏死及汇管区炎细胞浸润轻;B组达高峰;C组病变明显减轻,并可见增生的肝组织。各组大鼠的各项血清生化检测值均有显著性差异(P<0.05)。结论移植肝在术后第2天病理损伤程度均较轻,第7天相对严重,第14天明显减轻。肝功能生化指标的变化与病理学变化基本一致。Objective To investigate the changing rules of graft histology and function after liver transplantation among isogeneic rats. Methods Receptors of 51 rats were divided into three groups at random. Every group had 17 rats. The receptors of each group were executed on the 2 nd, 7 th and 14 th day respectively after transplantation. The pathological observation of liver samples was done under the microscope. The serum data of TB, ALT, GGT were measured. Result （1） The hepatocytes degenerated, necrosed and inflammatory cells infiltrated the portal areas of Group A after operations were lightened; it was on the high peak with the Group B. The liver pathological changes with Group C obviously eased and the hyperplasia of liver tissue appeared. （2） Every result of serum biochemistry was measured in every group rat after operation had significant difference （P 〈 0.05）. Conclusion The degree of the liver pathological injury is relatively slight on the 2nd day but relatively serious on the 7 th after operation. The liver pathological changes on the 14 th lightened obviously. The changes of the liver pathology and the biochemical data of the liver function basically conformed.

关 键 词：大鼠 肝移植 病理学 肝功能 

分 类 号：R657.3[医药卫生—外科学]