老年冠心病患者血浆非高密度脂蛋白胆固醇水平的差异  

The Difference between Serum non-High Density Lipoprotein Level in Elderly Patients with Coronary Heart Disease

作　　者：江柳月[1] 刘建平[1] 陶如琦[1] 金叔宣[1] 杜勇平[1] 宋玮[1] 王彬尧[1] 何奔[1] 

机构地区：[1]上海交通大学医学院附属仁济医院心内科,上海市200127

出　　处：《中国动脉硬化杂志》2007年第2期117-119,共3页Chinese Journal of Arteriosclerosis

基　　金：上海市自然科学基金(034119823)

摘　　要：目的探讨在老年冠心病患者的血清非高密度脂蛋白胆固醇的差异。方法选择120例行冠状动脉造影检查的老年患者,冠状动脉造影前空腹采静脉血,分析冠状动脉造影阳性组和对照组之间非高密度脂蛋白胆固醇与其它血脂数据(总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白)差异的显著性及非高密度脂蛋白胆固醇对冠状动脉病变程度的相关性。结果冠状动脉造影阳性组非高密度脂蛋白胆固醇水平显著高于阴性组2.99±1.08mmol/L,一支病变组为3.41±0.59mmol/L,两支病变组为3.70±1.30mmol/L,三支病变组为3.77±1.10mmol/L,(P<0.001)并且非高密度脂蛋白的水平随冠状动脉病变支数逐渐增高,与冠状动脉狭窄分数相关(r=0.36,P<0.001);而两组间甘油三酯,高密度脂蛋白水平无统计学差异(P>0.05)。结论血清非高密度脂蛋白胆固醇对于老年人是一项简便实用的冠心病风险评估指标。Aim To study the value of non-high-density lipaprotein level in evaluation of coronary artery disease（CAD） in eldedy patients. Methods 120 patients（75 cases and 45 controls） with selecting coronary angiography were enrolled in this case/control study. Fasting venous samples were ascertainted before coronary angiography and total cholesterol, triglycerid, high density lipaprotein cholesterol, low density lipaprotein cholesterol and non high-density lipaprotein cholesterol （n-HDLC） were measured respectively. The result of lipid analysis in the tow groups were studied by SPSS11.5 software. Results serum level of n-HDLC in the positive angiography group had significant higher than in the negative group 2.99±1.08 mmol/L, singlevesell group 3.41±0.59 mmol/L; double-vesellgroup 3.70±1.30 mmol/L; three-vesell group 3.77 ± 1.10 mmol/L, respectively （P 〈 0.001 ）. The serum n-HDLC level increased with the severity of coronary stonusis, and had a grade assiociation with coronary stenosis scores（r=0.326, P〈0.001）. There was no significant difference in serum triglycerid and high-density lipaprotein level hotween the two groups （ P 〉 0. 05 ）. Conclusion non-high-density lipaprotein is a low-cost and effective coronary artery disease risk assessment for elderly patients.

关 键 词：非高密度脂蛋白 胆固醇 冠状动脉疾病 老年人 

分 类 号：R543[医药卫生—心血管疾病]