A multichannel neural signal detecting module:Its design and test in animal experiments  

作　　者：Wang Yufeng Wang Zhigong Lu Xiaoying Gu Xiaosong Li Wenyuan Wang Huiling Jiang Zhenlin Lu Guangming K. P. Koch 

机构地区：[1]Institute of Radio Frequency ＆ Optical Electronics Integrated Circuits, Southeast University, Nanjing 210096, China [2]State KeyLaboratory of Bioelectronics, Southeast University, Nanjing 210096, China [3]Key Laboratory of Neural Regeneration of JiangsuProvince, Nantong University, Nantong 226001, China [4]Fraunhofer Institute for Biomedical Engineering, 66386 St. Ingbert, Germany

出　　处：《Progress in Natural Science:Materials International》2007年第6期675-680,共6页自然科学进展·国际材料（英文版）

基　　金：Supported by National Natural Science Foundation of China (Grant Nos 69825101 ,90377013 and 60121101)

摘　　要：A four-channel neural signal detecting module with an implantable 12-contact cuff electrode was designed for real-time neural signal recording on peripheral and central nerves. The mathematic coupling model between nerve and electronic system was analyzed. Electrode connection configurations were considered. The detecting circuit included an input coupling network, a pre-amplifier, and some filtering and notching stages. Shield guarding and the right-leg-driven circuit were developed for further elimination of common mode interference. By electrode switches, the module could cooperate with a nerve functional electrical stimulation circuit, building a neural channel bridge-connection system. It was tested by recording experiments on rat’s sciatic and spine nerves. The signals in spontaneous and evoked conditions have been captured successfully. In addition, an implantable neural signal detecting CMOS IC has been introduced.A four-channel neural signal detecting module with an implantable 12-contact cuff electrode was designed for real-time neural signal recording on peripheral and central nerves. The mathematic coupling model between nerve and electronic system was ana- lyzed. Electrode connection configurations were considered. The detecting circuit included an input coupling network, a pre-amplifier, and some filtering and notching stages. Shield guarding and the right-leg-driven circuit were developed for further elimination of common mode interference. By electrode switches, the module could cooperate with a nerve functional electrical stimulation circuit, building a neural channel bridge-connection system. It was tested by recording experiments on rat＇s sciatic and spine nerves. The signals in spontaneous and evoked conditions have been captured successfully. In addition, an implantable neural signal detecting CMOS IC has been introduced.

关 键 词：Cuff electrode quasi-tripolar configuration neural signal recording neural channel bridge-connection 

分 类 号：Q4-33[生物学—生理学] Q42