刺状鱼栖苔化学成分研究  

Studies on chemical constitutes of Acantophora spicifera

作　　者：史大永[1] 韩丽君[1] 孙杰[1] 袁兆慧[1] 杨永春[2] 石建功[2] 范晓[1] 

机构地区：[1]中国科学院海洋研究所 [2]中国医学科学院中国协和医科大学药物研究所,北京100050

出　　处：《中国中药杂志》2007年第11期1035-1037,共3页China Journal of Chinese Materia Medica

基　　金：国家863项目(2004AA25030;2001AA620503);中国科学院方向性创新项目(KZCX3-SW-215)

摘　　要：目的:研究红藻刺状鱼栖苔Acantophora spicifera化学成分。方法:利用正相和反相色谱,Sephadex LH-20色谱以及反相HPLC等手段进行分离纯化,应用MS,IR和ID,2D-NMR等方法鉴定结构。结果:从穗状鱼栖苔中分离鉴定了6个化合物,分别为aplysin(1),loloilide(2),(R)-(-)-dehydrovomifoliol(3),尿嘧啶(4),胸腺嘧啶(5),1-methoxy-4-(1-propenyl)benzene(6)。结论:所有化合物均为首次从本属海藻中分离得到,其中化合物6为首次从海洋生物中分离得到。Objective： To study the chemical constitutes ofAcantophora spicifera. Method： Compounds were isolated by normal phase silica gel and Sephadex LH -20 gel column chromatography, and reverse-phase HPLC, as well as recrystallization. Their structures were elucidated by spectroscopic methods. Result： Seven compounds were isolated from A. spicifera and their structures were identified as aplysin （1）, loloilide （2）, （R）-（ -）-dehydrovomifoliol （3）, uracil （4）, thymine （5）, 1-methoxy-4-（1-propenyl） benzene （6）. Conclusion： The compounds were obtained from this genus for the first time. Compound 6 was firstly obtained from marine organisms.

关 键 词：红藻 刺状鱼栖苔 化学成分 

分 类 号：R284.1[医药卫生—中药学]