猪眼虹膜力学特性的实验研究  

Experimental study on the mechanical characterization of porcine iris

作　　者：雷玉玺[1] 张昆亚[1] 宋红芳[1] 李婷[1] 刘志成[1] 

机构地区：[1]首都医科大学生物力学研究中心,北京100069

出　　处：《北京生物医学工程》2007年第3期308-311,共4页Beijing Biomedical Engineering

基　　金：国家自然科学基金(30670514)资助

摘　　要：研究猪眼虹膜的生物力学特性。通过模拟闭角型青光眼发生时眼睛前后房的力学环境,设计了一种实验方法并建立了闭角型青光眼的动物模型,在不破坏虹膜组织的完整性并尽量保持其活性的前提下,对猪眼虹膜的力学特性进行测试,得到了猪眼虹膜的面应变与前后房压强差之间的关系,可表示为δ=b0+b1lnΔP,它具有黏弹性性质。实验结果还可为解释青光眼致盲机理和临床分析青光眼的病理状况提供理论和实验基础。To qualify the mechanical properties of the iris during its passive deformation under the condition of glaucoma. Material and Methods： Experiments simulating the total pupillary block was performed on isolated poricne irises to measure the deformation brought by pressure difference between the posterior and anterior chamber, which described the passive mechanical behavior of the intact iris. Results： The relationship between the area strain （8） and the pressure difference（AP） was obtained as δ = b0 ＋ bI InΔP. The result indicates povine iris＇ s visco - elastic properties. Experimental results can offer reliable theoretical and experimental base for explaining and analyzing the blindness mechanism caused by Glaucoma.

关 键 词：闭角型青光眼 瞳孔阻滞 虹膜 生物力学 黏弹性 

分 类 号：R318.01[医药卫生—生物医学工程]