链球菌对抗生素产生耐药性的作用机制  

Antibiotic Resistance Mechanism of Streptococcus

作　　者：刘荻萩[1] 李艳华[1] 蔡雪辉[2] 陈维多[1] 

机构地区：[1]东北农业大学生命科学学院,哈尔滨150030 [2]中国农业科学院哈尔滨兽医研究所,哈尔滨150001

出　　处：《国外医药（抗生素分册）》2007年第3期103-107,共5页World Notes on Antibiotics

摘　　要：链球菌(Streptococcus)是一种重要的人畜共患病病原菌,对抗生素的耐药性日趋严重。由于特定基因的存在或改变,链球菌对抗生素的耐药机制主要表现为靶位改变、酶灭活、主动外排、通透性改变等。现从分子生物学角度,对链球菌耐药机制进行综述。Streptococcus is a wide spread pathogen that can infect both animals and human beings, Especially, the problem caused by antibiotic-resistant Streptococcus pneumoniae and Streptococcus suis have been becoming increasingly serious, which brings the great difficulties to disease diagnosis and therapy, and does considerable harm to the public health of human beings. The antibiotic-resistant mechanism of Streptococcus mainly includes target mutations , enzyme inactivation, active efflux system, as well as alteration of permeability. In this paper, the resistanoe mechanisms to macrolides, polypeptides, β-lactams, tetracydines, chloramphenicols and aminoglycosides were summarized.

关 键 词：链球菌 抗生素 耐药性 作用机制 

分 类 号：R978.1[医药卫生—药品]