阻塞性睡眠呼吸暂停综合征与高血压临床研究  

Clinical Study on Hypertension in Obstructive Sleep Apnea Syndrome

作　　者：张可[1] 李华[2] 

机构地区：[1]河南省直属机关第二门诊部,郑州市450003 [2]郑州大学第一附属医院,郑州市450052

出　　处：《医药论坛杂志》2007年第8期12-13,15,共3页Journal of Medical Forum

摘　　要：目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)与高血压的关系,为此种类型高血压的治疗提供依据。方法选取合并有OSAS的高血压患者32例作为实验组(OSAS组),单纯高血压患者36例作为对照组,同步进行24 h动态血压及多导睡眠仪监测;两组患者均常规低盐饮食、口服药物治疗3周,比较治疗前后动态血压变化;OSAS组降压效果差的患者同时接受持续气道正压(CPAP)治疗3周,观察血压控制情况。结果两组之间的白天平均收缩压(DSBP)、白天平均舒张压(DDBP)、夜间平均舒张压(NDBP)无明显差异;OSAS组的夜间平均收缩压(NSBP)明显高于对照组(P<0.05);药物治疗3周后,对照组血压较治疗前明显下降(P<0.05);OSAS组药物治疗前后无明显变化,再同时用CPAP治疗3周后血压显著下降。结论OSAS是引起高血压的原因之一,与OSAS有关的高血压患者单纯药物治疗效果欠佳,同时采用CPAP治疗有助于高血压的控制。Objective To investigate relationship between hypertension and obstructive sleep apnea syndrome（OSAS） ,provide some reference in clinical work. Methods 32 patients with hypertension and OSAS as experimental group,36 cases of single hypertension as control group ,all patients were monitored simultaneously by polysomnography （PSG） and ambulatory blood pressure （ABP）. Two groups conducted low salt diet and medicine for three weeks ,compared ABP before treatment and after treatment; the patients got poor results in decreasing pressure in experimental group are going on CPAP the same time for three weeks,observed the changes of blood pressure. Results There were no significant difference in mean DSBP, DDBP, NDBP between two groups;compared with control group, mean NSBP was higher remarkably（ P 〈0. 05） ; after the first three weeks treatment, pressure level of control group was decreased remarkably（ P 〈0. 05） ; that of experimental group was not deferred from before and after treatment, the blood pressure of patients was decreased remarkably after second three weeks of CPAP treatment. Conclusion OSAS may be considered as one of causes of hypertension, CPAP should be applied if patients with this special kind of hypertension could not get good control by only using medicine.

关 键 词：阻塞性睡眠呼吸暂停综合征 高血压 正压呼吸 

分 类 号：R563.8[医药卫生—呼吸系统]