抗抑郁药对肠系膜上动脉综合征伴抑郁研究  

To Evaluate Efficacy of Anti-depressant on Patients Suffered Superior Mesenteric Artery Syndrome with Depression

作　　者：蒋红梅[1] 卢艳如[1] 陈玉龙[1] 

机构地区：[1]郑州大学第一附属医院

出　　处：《医药论坛杂志》2007年第7期3-5,共3页Journal of Medical Forum

摘　　要：目的探讨抗抑郁疗法对肠系膜上动脉综合征伴抑郁及皮质醇变化的疗效。方法对30例肠系膜上动脉综合征行帕罗西汀治疗8周(治疗组),15例肠系膜上动脉综合征行常规疗法8周(对照组)。根据症状和HAMD评分对肠系膜上动脉综合征按轻、中度进行分类,并检测血清皮质醇,再进行对比观察。结果对照组治疗前后HAMD(17项)评分和皮质醇值大小差异无统计学意义;治疗组治疗前HAMD(17项)评分明显高于治疗后(P<0.01);皮质醇值治疗后明显小于治疗前(P<0.05);治疗组治疗前后HAMD(17项)减分率差异显著,治疗有效率为80%(24/30)。结论抗抑郁药(帕罗西汀)可以改变肠系膜上动脉综合征的压迫,改善临床症状,提高生活质量。Objective To evaluate the efficacy of anti-depressant treatment in superior mesenteric artery syndrome（SMAS） with depression and hydrocortisone. Methods 30 cases of anti-depressant group received paroxetine treatment for 8 weeks, 15 cases of control group received conventional treatment for 8 weeks. Superior mesenteric artery syndrome patients were classified into light, middle group according to the psychological condition and HAMD scales score. The serum hydrocorti- sone test was used between light, middle group and control group. Results Pre - cure and post - cure conventional treatment had no obvious difference on the HAMD scales score and hydrocortisone, the HAMD scale score of anti- depressant group is significantly higher than post - cure （ P 〈 0.01 ）. Hydrocortisone of anti - depressant group is significantly lower than that of pre - cure （ P 〈 0. 05 ）. The efficiency of anti - depressant treatment is 80% （24/30）. Conclusion Anti - depressant drug （ paroxetine） can alter symptom of SMAS, improve clinical symptom and quality of life.

关 键 词：肠系膜上动脉综合征 HAMD量表 抑郁 皮质醇 

分 类 号：R971.43[医药卫生—药品]