左氧氟沙星对慢性支气管炎急性加重期老年患者QTc离散度影响  

Effects of Levofloxacin on QTcd Interval in Elderly Patients Hospitalized with Acute Exacerbations of COPD

作　　者：归茜[1] 陈杰[1] 唐蓉蓉[1] 朱长清[1] 陈怡[1] 

机构地区：[1]上海交通大学医学院附属仁济医院,上海200001

出　　处：《中华医院感染学杂志》2007年第6期722-724,共3页Chinese Journal of Nosocomiology

摘　　要：目的研究左氧氟沙星对慢性支气管炎急性加重期老年患者QT离散度影响。方法124例患者接受左氧氟沙星静脉注射治疗10-14 d,分别在治疗前、第5天、治疗后检测12导联心电图（EKG）和常规血液生化。结果接受左氧氟沙星静脉治疗的患者校正QT间期（QTc）在治疗前后无明显变化,校正QT离散度（QTcd）延长明显。结论左氧氟沙星在慢性支气管炎急性加重期老年患者中,未能引起QTc间期明显延长,但可能延长QTcd间期,有潜在致心律失常的危险。OBJECTIVE To study the effects of levofloxacin on QT correction dispersion（QTcd） interval in elderly patients hospitalized with acute exacerbations of COPD （AECOPD）. METHODS Totally 124 patients received IV levofloxacin （500 mg qd） for 10-14 days. Evaluations included of 12-lead ECGs at baseline and blood examination before treatment, day 5 and after treatment. RESULTS QT correction（QTc） interval was no significant changes, but the QTcd interval was with significant prolongation. CONCLUSIONS IV levofloxacin could not cause QTc interval prolongation, but could make QTcd interval prolongation, which is a potential risk of arrhythmia in elderly patients with AECOPD.

关 键 词：慢性支气管炎急性加重期 左氧氟沙星 QTC离散度 

分 类 号：R974[医药卫生—药品]