复方甘草酸苷治疗特应性皮炎的临床及实验研究  

Clinical and experimental study on treatment of atopic dermatitis with glycyrrhizin

作　　者：涂彩霞[1] 张新军[1] 张蕴颖[1] 白明辉[1] 赵晔[1] 刘影[1] 黄畋[1] 

机构地区：[1]大连医科大学附属二院皮肤科,116027

出　　处：《中国麻风皮肤病杂志》2007年第5期393-395,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:复方甘草酸苷(美能)用于治疗特应性皮炎,观察复方甘草酸苷对IgE介导的小鼠皮炎动物模型的作用。方法:特应性皮炎患者84例,美能加皿治林片口服,对照组皿治林口服。以卵清蛋白(ovalbumin,OVA)诱导小鼠特应性皮炎为动物模型,研究美能对其血清IgE、腹部真皮炎症细胞浸润和血清某些细胞因子IL-2、IL-4、IFN-γ的影响。结果:临床观察显示84例患者口服皿治林加美能后与对照组相比,对特应性皮炎的疗效具有显著性差异。实验结果显示美能抑制血清IgE、真皮炎性细胞浸润、血清IL-4,上调IFN-γ,对IL-2无明显影响。结论:复方甘草酸苷对特应性皮炎具有抗炎、抗过敏作用。Objective： To determine the efficacy of glyeyrrhizin in the treatment of atopie dermatitis （AD） and the effect on animal model of IgE - mediated murine dermatitis. Methods： Eighty - four eases of AD were treated with glycyrrhizin and mizolastine, while in control group only mizolastine was administered, ovalbumin- induced murine dermatitis was used as an animal-model. The effect of glyeyrrhizin on dermal inflammatory infiltration cell count of the abdomen and serum level of IgE, IL- 2, IL- 4 and IFN -γ were examined. Results： There was significant difference in clinical efficacy between the two groups. Experiment studies showed that glyeyrrhizin suppressed serum level of IgE and IL - 4, and dermal inflammatory infiltration cell, and up - regulated IFN - γ, but had no effect on IL- 2. Conclusion： Glyeyrrhizin may be anti - inflammatory and anti - allergic in atopie dermatitis.

关 键 词：甘草酸苷 特应性皮炎 

分 类 号：R275[医药卫生—中医皮科]