端粒酶活性调控研究进展  

The Progress of Research about Regulation of Telomerase Activation

作　　者：潘永荣[1] 汉丽梅[1] 刘丹[1] 

机构地区：[1]沈阳农业大学,辽宁沈阳110161

出　　处：《畜牧兽医杂志》2007年第3期28-30,34,共4页Journal of Animal Science and Veterinary Medicine

摘　　要：端粒酶(telomerase)是真核生物细胞内的一种核糖核蛋白复合体,由基本的催化部分端粒酶反转录酶TERT(telomerase reverse transcriptase)和RNA组分TR(telomerase RNA)组成,是一种特殊的DNA聚合酶,具有延伸DNA末端的功能,能够维持端粒的长度和功能,RNA亚基为端粒的合成提供模板,TERT具有反转录酶活性。在大多数体细胞和原代细胞中,端粒酶无活性,但在肿瘤细胞中,端粒酶则被广泛激活,这是维持细胞分裂和端粒长度所必须的。Telomerase is a ribonucleoprotein complex in eukaryocyte,which is composed of telomerase reverse transcriptase （TERT） and telomerase RNA. Telomerase is a special DNA polymerase that can extend the terminal of DNA and maintain the length of telomere. Its RNA subunit provides template for telomere synthesis. TERT have reverse transcriptase activity. Telomerase activity was not detected in most somatic cell and primary cell,but was shown in most tumors. Telomerase is indispensable for telomere extension and maintenance of ceil division.

关 键 词：端粒酶 端粒 活性调节 

分 类 号：Q55[生物学—生物化学]