Asymmetric Synthesis and Crystal Structure of a Bioactive Morpholine Derivative  

作　　者：WANG Jian-Ping FU Yong-Ju WANG Jian-Ge QIN Jian-Hua CHEN Qing-Hua 

机构地区：[1]Department of Chemistry, Luoyang Normal University, Luoyang 471022,China [2]Chemical Engineering ＆ Pharmaceutics College, Henan Universityof Science and Technology, Luoyang 471003, China

出　　处：《Chinese Journal of Structural Chemistry》2007年第5期515-518,共4页结构化学（英文）

基　　金：Financially supported by the National Natural Science Foundation of China (No. 29672004)

摘　　要：A novel morpholine derivative was synthesized by Michael addition/internal nucleophilic substitution of 4-（L）-menthyloxy（1R,2S,5R）-butenolide with phenyl-glyalcohol under mild condition, and its structure was determined by X-ray diffraction. The target compound belongs to orthorhombic, space group P212121 with a = 5.7729（7）, b = 11.5032（14）, c = 25.161（3）A, Mr = 319.35, Z = 4, V = 1670.8（4）A^3, Dc = 1.270 g/cm3, μ（MoKα） = 0.094 mm^-1, F（000） = 680, Flack = 0.01（2）, R = 0.0398 and wR = 0.0914.A novel morpholine derivative was synthesized by Michael addition/internal nucleophilic substitution of 4-（L）-menthyloxy（1R,2S,5R）-butenolide with phenyl-glyalcohol under mild condition, and its structure was determined by X-ray diffraction. The target compound belongs to orthorhombic, space group P212121 with a = 5.7729（7）, b = 11.5032（14）, c = 25.161（3）A, Mr = 319.35, Z = 4, V = 1670.8（4）A^3, Dc = 1.270 g/cm3, μ（MoKα） = 0.094 mm^-1, F（000） = 680, Flack = 0.01（2）, R = 0.0398 and wR = 0.0914.

关 键 词：morpholine derivative α-phenyl-glyalcohol 4-（L）-menthyloxy-butenolide asymmetric synthesis 

分 类 号：O626.42[理学—有机化学]